Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells

L Peltier 1, 2 C Bendavid 1, 2 T Cavey 1, 2 M-L Island 2 M Doyard 2 P Leroyer 2 C Allain 2 M de Tayrac 3, 1 M Ropert 1, 2 O Loréal 2 P Guggenbuhl 1, 2
1 CHU Pontchaillou [Rennes]
2 NuMeCan - Nutrition, Métabolismes et Cancer
3 IGDR - Institut de Génétique et Développement de Rennes
Abstract : We aimed to study the mechanisms involved in bone-related iron impairment by using the osteoblast-like MG-63 cell line. Our results indicate that iron impact the S1P/S1PR signalizing axis and suggest that iron can affect the S1P process and favor the occurrence of osteoporosis during chronic iron overload.
Keywords : SPNS2 Osteoporosis Iron Osteoblast Hemochromatosis Sphingosine-1-phosphate
Document type :
Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01812519
Contributor : Laurent Jonchère <>
Submitted on : Monday, June 11, 2018 - 2:57:51 PM
Last modification on : Wednesday, September 5, 2018 - 4:12:02 PM

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UNIV-RENNES1 | IGDR | NUMECAN-CIMIAD | NUMECAN-EXPRES | BIOSIT | UR1-UFR-SVE | NUMECAN | UNIV-RENNES

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L Peltier, C Bendavid, T Cavey, M-L Island, M Doyard, et al.. Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells. Osteoporosis International, Springer Verlag, 2018, 29 (8), pp.1905-1915. ⟨10.1007/s00198-018-4531-8⟩. ⟨hal-01812519⟩

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