Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells - Archive ouverte HAL Access content directly
Journal Articles Osteoporosis International Year : 2018

Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells

Abstract

We aimed to study the mechanisms involved in bone-related iron impairment by using the osteoblast-like MG-63 cell line. Our results indicate that iron impact the S1P/S1PR signalizing axis and suggest that iron can affect the S1P process and favor the occurrence of osteoporosis during chronic iron overload.
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hal-01812519 , version 1 (11-06-2018)

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L Peltier, C Bendavid, T Cavey, M-L Island, M Doyard, et al.. Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells. Osteoporosis International, 2018, 29 (8), pp.1905-1915. ⟨10.1007/s00198-018-4531-8⟩. ⟨hal-01812519⟩
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