Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells

L Peltier (1, 2) , C Bendavid (1, 2) , T Cavey (1, 2) , M-L Island (2) , M Doyard (2) , P Leroyer (2) , C Allain (2) , M de Tayrac (3, 1) , M Ropert (1, 2) , Olivier Loréal (2) , P Guggenbuhl (1, 2)

1 CHU Pontchaillou [Rennes]
2 NuMeCan - Nutrition, Métabolismes et Cancer
3 IGDR - Institut de Génétique et Développement de Rennes

We aimed to study the mechanisms involved in bone-related iron impairment by using the osteoblast-like MG-63 cell line. Our results indicate that iron impact the S1P/S1PR signalizing axis and suggest that iron can affect the S1P process and favor the occurrence of osteoporosis during chronic iron overload.

Keywords: Iron; Osteoblast; Osteoporosis; SPNS2; Hemochromatosis; Sphingosine-1-phosphate

Domains: Life Sciences [q-bio]; Genetics

L Peltier, C Bendavid, T Cavey, M-L Island, M Doyard, et al.. Iron excess upregulates SPNS2 mRNA levels but reduces sphingosine-1-phosphate export in human osteoblastic MG-63 cells. Osteoporosis International, 2018, 29 (8), pp.1905-1915. ⟨10.1007/s00198-018-4531-8⟩. ⟨hal-01812519⟩