Skip to Main content Skip to Navigation
Journal articles

Reading cytosine modifications within chromatin

Abstract : Zinc-finger and homeodomain transcription factors have been shown in vitro to bind to recognition motifs containing a methylated CpG. However, accessing these motifs in vivo might be seriously impeded by the inclusion of DNA in nucleosomes and by the condensed structure adopted by chromatin formed on methylated DNA. Here, we discuss how oxidation of 5-methylcytosine into 5-hydroxymethylcytosine could provide the initial destabilizing clue for such transcription factors to get access to nucleosomal DNA and read epigenetic information.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01812520
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Monday, June 11, 2018 - 2:57:54 PM
Last modification on : Wednesday, February 24, 2021 - 3:20:59 PM

Links full text

Identifiers

Citation

Elise A Mahé, Thierry Madigou, Gilles Salbert. Reading cytosine modifications within chromatin. Transcription, Taylor & Francis, 2018, 9 (4), pp.240-247. ⟨10.1080/21541264.2017.1406435⟩. ⟨hal-01812520⟩

Share

Metrics

Record views

75