One-Pot Synthesis of Dihydropyrimidinones/Thiones Catalyzed by White Marble a Metamorphic Rock an Efficient and Reusable Catalyst for the Biginelli Reaction

K. El Mejdoubi (1) , B. Sallek (1) , H. Cherkaoui (1) , H. Chaair (2) , H. Oudadesse (3)

1 UIT - Université Ibn Tofaïl
2 FSTM - Faculte des sciences et Techniques Mohammedia [Casablanca]
3 ISCR - Institut des Sciences Chimiques de Rennes

In this work, we report a simple, efficient and green protocol for the synthesis of dihydropyrimidinones/thiones (products of Biginelli reaction) by the use of white marble as an effective heterogeneous catalyst. Short reaction times, high product yields, simple processing procedure and reusability of the catalyst are the superior characteristics of this protocol.

Mots clés: Biginelli reaction; 4-dihydropyrimidin-2(1H)-ones/thiones; white marble; green catalyst

Domaines: Catalyse; Chimie organique

K. El Mejdoubi, B. Sallek, H. Cherkaoui, H. Chaair, H. Oudadesse. One-Pot Synthesis of Dihydropyrimidinones/Thiones Catalyzed by White Marble a Metamorphic Rock an Efficient and Reusable Catalyst for the Biginelli Reaction. Kinetics and Catalysis, 2018, 59 (3), pp.290-295. ⟨10.1134/S0023158418030126⟩. ⟨hal-01833234⟩