Echocardiographic reference ranges for normal left atrial function parameters results from the EACVI NORRE study

Tadafumi Sugimoto (1) , Sébastien Robinet (1) , Raluca Dulgheru (1) , Anne Bernard (1, 2) , Federica Ilardi (1) , Laura Contu (1) , Karima Addetia , Luis Caballero (3) , George Kacharava , George D Athanassopoulos (4) , Daniele Barone , Monica Baroni , Nuno Cardim , Andreas Hagendorff (5) , Krasimira Hristova , Teresa Lopez , Gonzalo de La Morena (3) , Bogdan A Popescu , Martin Penicka , Tolga Ozyigit , Jose David Rodrigo Carbonero , Nico van de Veire , Ralph Stephan von Bardeleben , Dragos Vinereanu , Jose Luis Zamorano (6) , Yun Yun Go (1) , Stella Marchetta (1) , Alain Nchimi (1) , Monica Rosca , Andreea Calin , Marie Moonen (1) , Sara Cimino (1) , Julien Magne (7, 8) , Bernard Cosyns , Elena Galli (9, 10, 11) , Erwan Donal (9, 10, 11) , Gilbert Habib (12, 13) , Roberta Esposito , Maurizio Galderisi , Luigi P Badano , Roberto M Lang , Patrizio Lancellotti (1)

1 CHU-Liège - Centre Hospitalier Universitaire de Liège
2 CHU Trousseau [Tours]
3 Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia]
4 OCSC - Onassis Cardiac Surgery Center [Athens]
5 Universität Leipzig [Leipzig]
6 UAH - Universidad de Alcalá - University of Alcalá
7 Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges]
8 NET - Neuroépidémiologie Tropicale
9 CIC - Centre d'Investigation Clinique [Rennes]
10 CIC-IT Rennes
11 LTSI - Laboratoire Traitement du Signal et de l'Image
12 TIMONE - Hôpital de la Timone [CHU - APHM]
13 MEPHI - Microbes évolution phylogénie et infections

Aims - To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results - A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. Conclusion - The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

Domains: Life Sciences [q-bio]; Bioengineering

Tadafumi Sugimoto, Sébastien Robinet, Raluca Dulgheru, Anne Bernard, Federica Ilardi, et al.. Echocardiographic reference ranges for normal left atrial function parameters results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging, 2018, 19 (6), pp.630-638. ⟨10.1093/ehjci/jey018⟩. ⟨hal-01833888⟩