Long-term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice

Jodi L Pawluski (1, 2) , Mathieu Kuchenbuch (3) , Sarah Hadjadj (3) , Gabriel Dieuset (3) , Nathalie Costet (3) , Laurent Vercueil (4, 5) , Arnaud Biraben (3, 6) , Benoît Martin (3)

1 Irset - Institut de recherche en santé, environnement et travail
2 EHESP - École des Hautes Études en Santé Publique [EHESP]
3 LTSI - Laboratoire Traitement du Signal et de l'Image
4 CHU Grenoble
5 GIN - [GIN] Grenoble Institut des Neurosciences
6 CHU Pontchaillou [Rennes]

Keywords: valproate; mouse model; long-term prognosis; anti-epileptic drug; antiepileptic drug; absence epilepsy

Domains: Life Sciences [q-bio]; Pharmaceutical sciences; Pharmacology; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

Jodi L Pawluski, Mathieu Kuchenbuch, Sarah Hadjadj, Gabriel Dieuset, Nathalie Costet, et al.. Long-term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice. Epilepsia, 2018, 59 (7), pp.e109-e113. ⟨10.1111/epi.14454⟩. ⟨hal-01833892⟩