Humulene derivatives from Saharian Asteriscus graveolens

Abstract : Three new sesquiterpene-humulenes, (−)- asteriscunolides I (1), J (2) and (−)-(2Z,6E,9Z)-8-oxo-1α-acetoxy-2,6,9-humulatrien-12-oic acid (3) were isolated from the leaves-flowers of the Saharan medicinal plant Asteriscus graveolens along with six known compounds. The structures of the compounds were determined on the basis of spectroscopic mono and bidimensional NMR, mass spectrometry and by single-crystal X-ray diffraction. Compounds 1–3 were evaluated for cytotoxic assay, no significant activity was detected.
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L. Hammoud, F. Leon, I. Brouard, J. Gonzalez-Platas, S. Benayache, et al.. Humulene derivatives from Saharian Asteriscus graveolens. Tetrahedron Letters, 2018, 59 (27), pp.2668-2670. ⟨10.1016/j.tetlet.2018.05.079⟩. ⟨hal-01835019⟩



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