Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling

C. Rubio-Patiño (1) , J.P. Bossowski (1) , E. Chevet (2) , J.-E. Ricci (1)

1 C3M - Centre méditerranéen de médecine moléculaire
2 COSS - Chemistry, Oncogenesis, Stress and Signaling

The ability of a tumor cell to cope with environmental and intracellular stress depends on its capacity to activate appropriate adaptive pathways. As such, the endoplasmic reticulum (ER) adjusts the adaptive capacity of tumor cells by engaging the unfolded protein response (UPR). The UPR maintains the functionality of the secretory pathway, thereby allowing tumor cells to shape their microenvironment, thus likely determining the nature of the tumor immune response. Consequently, this makes the UPR very relevant in the context of cancer therapeutics. We focus here on inositol-requiring enzyme 1α (IRE1) and compile novel molecular mechanisms demonstrating that tumoral UPR controls the tumor microenvironment (TME) and the immune response, therefore opening potential novel therapeutic avenues. © 2018 Elsevier Ltd

Mots clés: cancer; endoplasmic reticulum; immune response; nutrition; stress

Domaines: Cancer

C. Rubio-Patiño, J.P. Bossowski, E. Chevet, J.-E. Ricci. Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling. Trends in Molecular Medicine, 2018, 24 (7), pp.607-614. ⟨10.1016/j.molmed.2018.05.005⟩. ⟨hal-01835398⟩