A. So, M. Furlong, and A. Heddini, Globalisation and antibiotic resistance, BMJ, vol.341, issue.sep21 3, p.5116, 2010.
DOI : 10.1136/bmj.c5116

M. Bassetti, M. Merelli, C. Temperoni, and A. Astilean, New antibiotics for bad bugs: where are we?, Annals of Clinical Microbiology and Antimicrobials, vol.12, issue.1, p.22, 2013.
DOI : 10.1128/AAC.02106-12

H. Boucher, G. Talbot, J. Bradley, J. Edwards, D. Gilbert et al., Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.39, issue.1, pp.1-12, 2009.
DOI : 10.1086/591389

A. Corona and R. Colombo, Towards the end of the antibiotic era: let???s save the ancient soldier Colistin!, Intensive Care Medicine, vol.17, issue.10, pp.1660-1661, 2013.
DOI : 10.3201/eid1710.110655

, Antimicrobial resistance: global report on surveillance, WHO World Health Organization, p.256, 2014.

J. Carlet, World Alliance against antibiotic resistance (WAAR): safeguarding antibiotics, Intensive Care Medicine, vol.18, issue.10, pp.1723-1724, 2012.
DOI : 10.1111/j.1469-0691.2011.03702.x

J. Paiva, Adding risk factors for potentially resistant pathogens, increasing antibiotic pressure and risk creating the ???untreatable bacteria???: time to change direction, Intensive Care Medicine, vol.37, issue.4, pp.779-781, 2013.
DOI : 10.1007/s00134-011-2245-x

P. Damas, J. Canivet, D. Ledoux, M. Monchi, P. Melin et al., Selection of resistance during sequential use of preferential antibiotic classes, Intensive Care Medicine, vol.48, issue.1, pp.67-74, 2006.
DOI : 10.7326/0003-4819-134-4-200102200-00014

J. Timsit, S. Harbarth, and J. Carlet, De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU, Intensive Care Medicine, vol.355, issue.Suppl 1, pp.1580-1582, 2014.
DOI : 10.1016/S0140-6736(00)90015-1

S. Visscher, C. Schurink, W. Melsen, P. Lucas, and M. Bonten, Effects of systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated patients, Intensive Care Medicine, vol.159, issue.4, pp.692-699, 2008.
DOI : 10.1164/ajrccm.159.1.9803097

N. Brusselaers, D. Vogelaers, and S. Blot, The rising problem of antimicrobial resistance in the intensive care unit, Annals of Intensive Care, vol.1, issue.1, p.47, 2011.
DOI : 10.1016/j.ajic.2007.06.009

A. Michalopoulos and M. Falagas, Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients, Annals of Intensive Care, vol.1, issue.1, p.30, 2011.
DOI : 10.1097/INF.0b013e3182064bfe

H. Hanberger, D. Arman, H. Gill, V. Jindrak, S. Kalenic et al., Surveillance of microbial resistance in European Intensive Care Units: a first report from the Care-ICU programme for improved infection control, Intensive Care Medicine, vol.34, issue.suppl 1, pp.91-100, 2009.
DOI : 10.1016/S0140-6736(05)17783-6

M. Bassetti, D. Waele, J. Eggimann, P. Garnacho-montero, J. Kahlmeter et al., Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria, Intensive Care Medicine, vol.254, issue.12, pp.776-795, 2015.
DOI : 10.1097/SLA.0b013e31822ade48

D. Atkins, D. Best, P. Briss, M. Eccles, Y. Falck-ytter et al., Grading quality of evidence and strength of recommendations, BMJ, vol.328, p.1490, 2004.

G. Guyatt, A. Oxman, G. Vist, R. Kunz, Y. Falck-ytter et al., GRADE: an emerging consensus on rating quality of evidence and strength of recommendations, BMJ, vol.336, issue.7650, pp.924-926, 2008.
DOI : 10.1136/bmj.39489.470347.AD

, Grading quality of evidence and strength of recommendations, GRADE Working Group BMJ, vol.328, p.1490, 2004.

K. Fitch, S. Bernstein, M. Aguilar, and B. Burnand, The RAND/ UCLA appropriateness method user's manual. RAND, Santa Monica 19. DiazGranados CA (2012) Prospective audit for antimicrobial stewardship in intensive care: impact on resistance and clinical outcomes, Am J Infect Control, vol.40, pp.526-529, 2001.

J. Kim, J. Chung, S. Choi, H. Jang, S. Hong et al., Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial, Critical Care, vol.16, issue.1, p.28, 2012.
DOI : 10.1016/j.ijheh.2008.07.001

S. Nijssen, A. Fluit, D. Van-de-vijver, J. Top, R. Willems et al., Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria, Intensive Care Medicine, vol.3, issue.3, pp.512-519, 2010.
DOI : 10.7326/0003-4819-130-2-199901190-00006

R. Kaki, M. Elligsen, S. Walker, A. Simor, L. Palmay et al., Impact of antimicrobial stewardship in critical care: a systematic review, Journal of Antimicrobial Chemotherapy, vol.6, issue.7, pp.1223-1230, 2011.
DOI : 10.1186/1471-2288-6-54
URL : https://academic.oup.com/jac/article-pdf/66/6/1223/2135278/dkr137.pdf

S. Kuster, C. Ruef, B. Ledergerber, A. Hintermann, C. Deplazes et al., Quantitative Antibiotic Use in Hospitals: Comparison of Measurements, Literature Review, and Recommendations for a Standard of Reporting, Infection, vol.326, issue.6, pp.549-559, 2008.
DOI : 10.1590/S1020-49892006000700013

E. Giantsou, N. Liratzopoulos, E. Efraimidou, M. Panopoulou, E. Alepopoulou et al., De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate, Intensive Care Medicine, vol.122, issue.6, pp.1533-1540, 2007.
DOI : 10.1164/ajrccm.165.7.2105078

J. Garnacho-montero, A. Gutierrez-pizarraya, A. Escoresca-ortega, Y. Corcia-palomo, E. Fernandez-delgado et al., De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock, Intensive Care Medicine, vol.53, issue.Suppl 2, pp.32-40, 2014.
DOI : 10.1093/cid/cir475

D. Mokart, G. Slehofer, J. Lambert, A. Sannini, L. Chow-chine et al., De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study, Intensive Care Medicine, vol.3, issue.Suppl 2, pp.41-49, 2014.
DOI : 10.1007/s00134-011-2344-8

J. Fagon, J. Chastre, M. Wolff, C. Gervais, S. Parer-aubas et al., Invasive and Noninvasive Strategies for Management of Suspected Ventilator-Associated Pneumonia, Annals of Internal Medicine, vol.132, issue.8, pp.621-630, 2000.
DOI : 10.7326/0003-4819-132-8-200004180-00004

J. Swanson, G. Wood, M. Croce, E. Mueller, B. Boucher et al., Utility of Preliminary Bronchoalveolar Lavage Results in Suspected Ventilator-Associated Pneumonia, The Journal of Trauma: Injury, Infection, and Critical Care, vol.65, issue.6, pp.1271-1277, 2008.
DOI : 10.1097/TA.0b013e3181574d6a

, A randomized trial of diagnostic techniques for ventilator-associated pneumonia, Canadian Critical Care Trials Group N Engl J Med, vol.355, pp.2619-2630, 2006.

O. Horo, J. Thompson, D. Safdar, and N. , Is the Gram Stain Useful in the Microbiologic Diagnosis of VAP? A Meta-analysis, Clinical Infectious Diseases, vol.83, issue.4, pp.551-561, 2012.
DOI : 10.1093/bja/83.6.845

A. Galar, J. Yuste, M. Espinosa, F. Guillen-grima, S. Hernaez-crespo et al., Clinical and economic impact of rapid reporting of bacterial identification and antimicrobial susceptibility results of the most frequently processed specimen types, European Journal of Clinical Microbiology & Infectious Diseases, vol.27, issue.9, 2012.
DOI : 10.1086/504934

, Eur J Clin Microbiol Infect Dis, vol.31, pp.2445-2452

J. Kerremans, P. Verboom, T. Stijnen, L. Hakkaart-van-roijen, W. Goessens et al., Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use, Journal of Antimicrobial Chemotherapy, vol.61, issue.2, pp.428-435, 2008.
DOI : 10.1093/jac/dkm497

A. Vlek, M. Bonten, C. Boel, K. Perez, R. Olsen et al., Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs, PLoS One Arch Pathol Lab Med, vol.7, issue.137, pp.32589-341247, 2012.

S. Lasocki, A. Scanvic, L. Turdu, F. Restoux, A. Mentec et al., Evaluation of the Binax NOW Streptococcus pneumoniae urinary antigen assay in intensive care patients hospitalized for pneumonia, Intensive Care Medicine, vol.12, issue.11, pp.1766-1772, 2006.
DOI : 10.7326/0003-4819-138-1-200301070-00010

M. Falguera, A. Ruiz-gonzalez, J. Schoenenberger, C. Touzon, I. Gazquez et al., Prospective, randomised study to compare empirical treatment versus targeted treatment on the basis of the urine antigen results in hospitalised patients with community-acquired pneumonia, Thorax, vol.65, issue.2, pp.101-106, 2010.
DOI : 10.1136/thx.2009.118588

M. Matta, S. Kerneis, N. Day, M. Lescat, A. Hoi et al., Do clinicians consider the results of the BinaxNOW Streptococcus pneumoniae urinary antigen test when adapting antibiotic regimens for pneumonia patients?, Clinical Microbiology and Infection, vol.16, issue.9, pp.1389-1393, 2010.
DOI : 10.1111/j.1469-0691.2010.03088.x

P. Depuydt, D. Benoit, D. Vogelaers, J. Decruyenaere, D. Vandijck et al., Systematic surveillance cultures as a toolto predict involvement of multidrug antibiotic resistant bacteria in ventilator-associated pneumonia, Intensive Care Medicine, vol.64, issue.4, pp.675-682, 2008.
DOI : 10.1164/ajrccm.160.2.9812034

B. Jung, M. Sebbane, G. Chanques, P. Courouble, D. Verzilli et al., Previous endotracheal aspirate allows guiding the initial treatment of ventilator-associated pneumonia, Intensive Care Medicine, vol.32, issue.4, pp.101-107, 2009.
DOI : 10.1164/ajrccm.159.6.9808030

N. Joseph, S. Sistla, T. Dutta, A. Badhe, and S. Parija, Ventilator-associated pneumonia: role of colonizers and value of routine endotracheal aspirate cultures, International Journal of Infectious Diseases, vol.14, issue.8, pp.723-729, 2010.
DOI : 10.1016/j.ijid.2010.02.2248

L. Armand-lefevre, C. Angebault, F. Barbier, E. Hamelet, G. Defrance et al., ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.57, issue.3, pp.1488-1495
DOI : 10.1128/AAC.01823-12

C. Routsi, M. Pratikaki, E. Platsouka, C. Sotiropoulou, V. Papas et al., Risk factors for carbapenem-resistant Gram-negative bacteremia in intensive care unit patients, Intensive Care Medicine, vol.31, issue.Suppl, pp.1253-1261, 2013.
DOI : 10.1097/01.CCM.0000060015.77443.31

K. Razazi, L. Derde, M. Verachten, P. Legrand, P. Lesprit et al., Clinical impact and risk factors for colonization with extended-spectrum ??-lactamase-producing bacteria in the intensive care unit, Intensive Care Medicine, vol.171, issue.Suppl 1, pp.1769-1778, 2012.
DOI : 10.1164/rccm.200405-644ST

D. Andes and W. Craig, Treatment of infections with ESBL-producing organisms: pharmacokinetic and pharmacodynamic considerations, Clinical Microbiology and Infection, vol.11, issue.6, pp.10-17, 2005.
DOI : 10.1111/j.1469-0691.2005.01265.x
URL : https://doi.org/10.1111/j.1469-0691.2005.01265.x

H. Nguyen, K. Shier, and C. Graber, Determining a clinical framework for use of cefepime and beta-lactam/beta-lactamase inhibitors in the treatment of infections caused by extended-spectrum-beta-lactamaseproducing Enterobacteriaceae, 2014.

, J Antimicrob Chemother, vol.69, pp.871-880

G. Aubert, A. Carricajo, A. Vautrin, S. Guyomarc-'h, N. Fonsale et al., Impact of restricting fluoroquinolone prescription on bacterial resistance in an intensive care unit, Journal of Hospital Infection, vol.59, issue.2, pp.83-89, 2005.
DOI : 10.1016/j.jhin.2004.07.016

S. Nseir, D. Pompeo, C. Soubrier, S. Delour, P. Lenci et al., First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit*, Critical Care Medicine, vol.33, issue.2, pp.283-289, 2005.
DOI : 10.1097/01.CCM.0000152230.53473.A1

P. Charbonneau, J. Parienti, P. Thibon, M. Ramakers, C. Daubin et al., Fluoroquinolone Use and Methicillin-Resistant Staphylococcus aureus Isolation Rates in Hospitalized Patients: A Quasi Experimental Study, Clinical Infectious Diseases, vol.39, issue.4, pp.778-784, 2006.
DOI : 10.1086/422641

A. Goorhuis, D. Bakker, J. Corver, S. Debast, C. Harmanus et al., Infection Due to a New Hypervirulent Strain, Polymerase Chain Reaction Ribotype 078, Clinical Infectious Diseases, vol.13, issue.9, pp.1162-1170, 2008.
DOI : 10.3201/eid1407.071641

L. Drieux, F. Brossier, O. Duquesnoy, A. A. Robert, J. Sougakoff et al., Increase in hospital-acquired bloodstream infections caused by extended spectrum ??-lactamase-producing Escherichia coli in a large French teaching hospital, European Journal of Clinical Microbiology & Infectious Diseases, vol.10, issue.9, pp.491-498, 2009.
DOI : 10.3201/eid1009.030969

M. Ortega, F. Marco, A. Soriano, M. Almela, J. Martinez et al., Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome, Journal of Antimicrobial Chemotherapy, vol.42, issue.3, pp.568-574, 2009.
DOI : 10.1086/500663

C. Costelloe, C. Metcalfe, A. Lovering, D. Mant, and A. Hay, Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis, BMJ, vol.340, issue.may18 2, p.2096, 2010.
DOI : 10.1136/bmj.c2096

S. Berman, E. Johnson, C. Nakatsu, M. Alkan, R. Chen et al., Burden of Infection in Patients with End-Stage Renal Disease Requiring Long-Term Dialysis, Clinical Infectious Diseases, vol.24, issue.4, pp.1747-1753, 2004.
DOI : 10.1016/S0272-6386(05)80009-5

E. Solh, A. Pietrantoni, C. Bhat, A. Bhora, M. Berbary et al., Indicators of Potentially Drug-Resistant Bacteria in Severe Nursing Home--Acquired Pneumonia, Clinical Infectious Diseases, vol.154, issue.8, pp.474-480, 2004.
DOI : 10.1001/archinte.1994.00420080076008

E. Polverino, P. Dambrava, C. Cilloniz, V. Balasso, M. Marcos et al., Nursing home-acquired pneumonia: a 10 year single-centre experience, Thorax, vol.65, issue.4, pp.354-359, 2010.
DOI : 10.1136/thx.2009.124776

A. Scanvic, L. Denic, S. Gaillon, P. Giry, A. Andremont et al., Duration of Colonization by Methicillin-Resistant Staphylococcus aureus after Hospital Discharge and Risk Factors for Prolonged Carriage, Clinical Infectious Diseases, vol.13, issue.1, pp.1393-1398, 2001.
DOI : 10.1007/BF02026130

O. Lambotte, J. Timsit, M. Garrouste-orgeas, B. Misset, A. Benali et al., The Significance of Distal Bronchial Samples with Commensals in Ventilator-Associated Pneumonia, Chest, vol.122, issue.4, pp.1389-1399, 2002.
DOI : 10.1378/chest.122.4.1389

V. Fowler, . Jr, H. Boucher, G. Corey, E. Abrutyn et al., New England Journal of Medicine, vol.355, issue.7, pp.653-665, 2006.
DOI : 10.1056/NEJMoa053783

K. Murray, J. Zhao, S. Davis, R. Kullar, K. Kaye et al., Early Use of Daptomycin Versus Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia With Vancomycin Minimum Inhibitory Concentration >1 mg/L: A Matched Cohort Study, Clinical Infectious Diseases, vol.32, issue.11, pp.1562-1569, 2013.
DOI : 10.1002/j.1875-9114.2011.01017.x

R. Wunderink, M. Niederman, M. Kollef, A. Shorr, M. Kunkel et al., Linezolid in Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia: A Randomized, Controlled Study, Clinical Infectious Diseases, vol.33, issue.9, pp.621-629, 2012.
DOI : 10.1097/01.CCM.0000178180.61305.1D

N. Patel, M. Pai, K. Rodvold, B. Lomaestro, G. Drusano et al., Vancomycin: We Can't Get There From Here, Clinical Infectious Diseases, vol.34, issue.6, pp.969-974, 2011.
DOI : 10.1016/j.ijantimicag.2009.08.005

R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach et al., Surviving Sepsis Campaign, Critical Care Medicine, vol.41, issue.2, pp.165-228, 2012.
DOI : 10.1097/CCM.0b013e31827e83af

K. Yu and P. Wyer, Evidence Behind the 4-Hour Rule for Initiation of Antibiotic Therapy in Community-Acquired Pneumonia, Annals of Emergency Medicine, vol.51, issue.5, pp.651-662, 2008.
DOI : 10.1016/j.annemergmed.2007.10.022

S. Silber, C. Garrett, R. Singh, A. Sweeney, C. Rosenberg et al., Early Administration of Antibiotics Does Not Shorten Time to Clinical Stability in Patients With Moderate-to-Severe Community-Acquired Pneumonia *, Chest, vol.124, issue.5, pp.1798-1804, 2003.
DOI : 10.1378/chest.124.5.1798

, Consensus conference on bacterial meningitis. Short text, 17th Consensus conference, pp.175-186, 2009.

F. Sime, M. Roberts, S. Peake, . J. Lipman, and J. Roberts, Does betalactam pharmacokinetic variability in critically Ill patients justify therapeutic drug monitoring? A systematic review, p.35, 2012.

M. Pletz and . J. Lipman, Clinical measures for increased creatinine clearances and suboptimal antibiotic dosing, Intensive Care Medicine, vol.41, issue.7, pp.1322-1324, 2013.
DOI : 10.1111/j.1445-5994.2009.02160.x

P. Povoa, I. Spriet, and J. Zahar, Antibiotic dosing in the critically ill: asking the same questions but expecting different answers, Intensive Care Medicine, vol.78, issue.11, pp.1780-1782, 2014.
DOI : 10.1371/journal.pone.0049845

A. Udy, J. Roberts, and . J. Lipman, Clinical implications of antibiotic pharmacokinetic principles in the critically ill, Intensive Care Medicine, vol.54, issue.Suppl 1, pp.2070-2082, 2013.
DOI : 10.1093/cid/cis286

D. Chatellier, M. Jourdain, J. Mangalaboyi, F. Ader, C. Chopin et al., Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure, Intensive Care Medicine, vol.28, issue.2, pp.214-217, 2002.
DOI : 10.1007/s00134-001-1170-9

W. Craig, State???of???the???Art Clinical Article: Pharmacokinetic/Pharmacodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men, Clinical Infectious Diseases, vol.26, issue.1, pp.1-10, 1998.
DOI : 10.1086/516284

J. Roberts, S. Paul, M. Akova, M. Bassetti, D. Waele et al., DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current ??-Lactam Antibiotic Doses Sufficient for Critically Ill Patients?, Clinical Infectious Diseases, vol.50, issue.6, pp.1072-1083, 2014.
DOI : 10.1128/AAC.00144-06
URL : https://hal.archives-ouvertes.fr/hal-01954093

J. Mohr, A. Wanger, and J. Rex, Pharmacokinetic/pharmacodynamic modeling can help guide targeted antimicrobial therapy for nosocomial gram-negative infections in critically ill patients, Diagnostic Microbiology and Infectious Disease, vol.48, issue.2, pp.125-130, 2004.
DOI : 10.1016/j.diagmicrobio.2003.09.010

C. Li, X. Du, J. Kuti, and D. Nicolau, Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections, Antimicrobial Agents and Chemotherapy, vol.51, issue.5, pp.1725-1730, 2007.
DOI : 10.1128/AAC.00294-06

M. Falagas, G. Tansarli, K. Ikawa, and K. Vardakas, Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis, Clin Infect Dis, vol.56, pp.272-282, 2013.

H. Spapen, J. Van-doorn, K. Diltoer, M. Verbrugghe, W. Jacobs et al., Retrospective evaluation of possible renal toxicity associated with continuous infusion of vancomycin in critically ill patients, Annals of Intensive Care, vol.1, issue.1, p.26, 2011.
DOI : 10.1378/chest.09-2453

J. Roberts, F. Taccone, A. Udy, J. Vincent, F. Jacobs et al., ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.55, issue.6, pp.2704-2709, 2011.
DOI : 10.1128/AAC.01708-10

M. Abdul-aziz, J. Dulhunty, R. Bellomo, . J. Lipman, and J. Roberts, Continuous beta-lactam infusion in critically ill patients: the clinical evidence, Annals of Intensive Care, vol.2, issue.1, p.37, 2012.
DOI : 10.1086/514622

M. Legrand, M. A. Schlemmer, B. Azoulay, E. Gachot, and B. , The strategy of antibiotic use in critically ill neutropenic patients, Annals of Intensive Care, vol.1, issue.1, p.22, 2011.
DOI : 10.1016/j.bbmt.2008.12.505

I. Gyssens, W. Kern, and D. Livermore, The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients, Haematologica, vol.98, issue.12, pp.1821-1825, 2013.
DOI : 10.3324/haematol.2013.091769

J. Chastre, M. Wolff, J. Fagon, S. Chevret, F. Thomas et al., Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults, JAMA, vol.290, issue.19, pp.2588-2598, 2003.
DOI : 10.1001/jama.290.19.2588

N. Singh, P. Rogers, C. Atwood, M. Wagener, and V. Yu, Short-course Empiric Antibiotic Therapy for Patients with Pulmonary Infiltrates in the Intensive Care Unit, American Journal of Respiratory and Critical Care Medicine, vol.11, issue.2, pp.505-511, 2000.
DOI : 10.1093/clinids/24.2.211

L. Bouadma, C. Luyt, F. Tubach, C. Cracco, A. Alvarez et al., Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial, The Lancet, vol.375, issue.9713, pp.463-474, 2010.
DOI : 10.1016/S0140-6736(09)61879-1

D. Matthaiou, G. Ntani, M. Kontogiorgi, G. Poulakou, A. Armaganidis et al., An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients, Intensive Care Medicine, vol.52, issue.6, pp.940-949, 2012.
DOI : 10.1093/cid/cir063

T. Havey, R. Fowler, and N. Daneman, Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis, Critical Care, vol.15, issue.6, p.267, 2011.
DOI : 10.1001/jama.283.12.1583

Y. Chong, S. Moon, K. Bang, H. Park, S. Park et al., ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.57, issue.3, pp.1150-1156, 2013.
DOI : 10.1128/AAC.01021-12

G. Thwaites, J. Edgeworth, E. Gkrania-klotsas, A. Kirby, R. Tilley et al., Clinical management of Staphylococcus aureus bacteraemia, The Lancet Infectious Diseases, vol.11, issue.3, pp.208-222, 2011.
DOI : 10.1016/S1473-3099(10)70285-1

R. Rimawi, M. Mazer, D. Siraj, M. Gooch, and P. Cook, Impact of Regular Collaboration Between Infectious Diseases and Critical Care Practitioners on Antimicrobial Utilization and Patient Outcome*, Critical Care Medicine, vol.41, issue.9, pp.2099-2107, 2013.
DOI : 10.1097/CCM.0b013e31828e9863

D. Waele, J. Bassetti, and M. , Impact of de-escalation on ICU patients??? prognosis, Intensive Care Medicine, vol.40, issue.10, pp.1583-1585
DOI : 10.1097/MCC.0000000000000124

G. Kapoor and S. Saigal, De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance, Intensive Care Medicine, vol.40, issue.8 Suppl, p.1618, 2014.
DOI : 10.1007/s00134-013-3077-7

M. Leone, C. Bechis, and K. Baumstarck, De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance, of course!, Intensive Care Medicine, vol.40, issue.10, p.1619, 2014.
DOI : 10.1007/s00134-013-3077-7

B. Silva, R. Andriolo, A. Atallah, and R. Salomao, De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock, Cochrane Database of Systematic Reviews, vol.12, issue.6, p.7934, 2013.
DOI : 10.1002/14651858.CD007934.pub2

M. Leone, C. Bechis, K. Baumstarck, J. Lefrant, J. Albanese et al., De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial, Intensive Care Medicine, vol.17, issue.8 Suppl, pp.1399-1408, 2014.
DOI : 10.1186/cc12849
URL : https://hal.archives-ouvertes.fr/hal-01945691

D. Kofteridis, C. Alexopoulou, A. Valachis, S. Maraki, D. Dimopoulou et al., Aerosolized plus Intravenous Colistin versus Intravenous Colistin Alone for the Treatment of Ventilator???Associated Pneumonia: A Matched Case???Control Study, Clinical Infectious Diseases, vol.51, issue.11, pp.1238-1244, 2010.
DOI : 10.1086/657242

G. Nair and M. Niederman, Ventilator-associated pneumonia: present understanding and ongoing debates, Intensive Care Medicine, vol.309, issue.Suppl 4, pp.34-48, 2015.
DOI : 10.1001/jama.2013.5154

L. Palmer and G. Smaldone, Reduction of Bacterial Resistance with Inhaled Antibiotics in the Intensive Care Unit, American Journal of Respiratory and Critical Care Medicine, vol.135, issue.10, pp.1225-1233, 2014.
DOI : 10.1164/ajrccm.162.5.9908088

N. Daneman, S. Sarwar, R. Fowler, B. Cuthbertson, and D. Su, Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis, The Lancet Infectious Diseases, vol.13, issue.4, pp.328-341, 2013.
DOI : 10.1016/S1473-3099(12)70322-5

M. Kollef, J. Chastre, M. Clavel, M. Restrepo, B. Michiels et al., A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia, Critical Care, vol.16, issue.6, p.218, 2012.
DOI : 10.1164/rccm.201102-0349OC