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, topic: Oxazolo[4,5-b]pyrazines FULL PAPER Functionalizations of 2-arylated oxazolo[4,5-b]pyrazines are reported. Access to the corresponding iodides was investigated, and deprotolithiation in the presence of a zinc-based in situ trap proved to be the most efficient approach. The observed regioselectivities were analysed in the light of the calculated pKa values

, The various halogenated ketones were next involved in copper-catalyzed two-fold C-N bond formation in order to obtain fused systems based on 2- aminopyrimidines. Besides potential antibacterial effect, reached 2- aminobenzothiopyrano, ?M) and CDK2/cyclin A (IC50: 2.0 ?M) kinases

N. Bisballe, M. Hedidi, C. S. Demmer, F. Chevallier, T. Roisnel et al., , 201800481.

, Accepted Manuscript European Journal of Organic Chemistry