tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion

Abstract : Two compounds () and () containing -butylphenol groups were, for the first time, produced during the culture of , a bacterial strain associated with the crustose lichen, . Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive.
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Thi-Bach-Le Nguyen, Olivier Delalande, Isabelle Rouaud, Solenn Ferron, Laura Chaillot, et al.. tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion. Molecules, MDPI, 2018, 23 (8), pp.1951. ⟨10.3390/molecules23081951⟩. ⟨hal-01862458⟩

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