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Journal articles
Synthesis, spectral characterization, molecular modeling, antibacterial and antioxidant activities and stability study of binuclear Pd(II) and Ru(III) complexes with novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl)methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] ligand Application to detection of cholesterol
Abstract : A novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl) methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] Schiff base (L) and its binuclear palladium and ruthenium complexes have been prepared and characterized by ESI-MS, elemental analysis, NMR (H NMR, C NMR, COSY, NEOSY and HSQC), FT-IR, ATR, UV-Visible spectra, TGA measurements, conductivity and cyclic voltammetry. The experimental results and the molecular parameters calculated using DFT method revealed a square planar geometry around Pd and octahedral geometry around ruthenium metal. The antibacterial activity of the ligand L and its complexes was evaluated against different human bacteria. In addition, the formation constants of the synthesized Schiff base-metal complexes and the systems formed with these chelates and cholesterol were estimated using spectrophotometric technique. The detection of cholesterol using novel Pd and Ru Schiff base complexes was studied using fluorometric method, and the measurements showed that the sensitive fluorometric response towards cholesterol analysis was determined using palladium complex. The limit of detection (LOD) of cholesterol calculated using this complex (4.6 μM) is lower (better) than LOD found using ruthenium complex (19.1 μM) and different compounds previously published around linear range of 0-5 mM.
Cited literature [48 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01862497
Contributor : Laurent Jonchère <>
Submitted on : Thursday, September 20, 2018 - 11:13:36 AM
Last modification on : Tuesday, January 12, 2021 - 4:45:56 PM
Long-term archiving on: : Friday, December 21, 2018 - 1:27:32 PM
Contributor : Laurent Jonchère <>
Submitted on : Thursday, September 20, 2018 - 11:13:36 AM
Last modification on : Tuesday, January 12, 2021 - 4:45:56 PM
Long-term archiving on: : Friday, December 21, 2018 - 1:27:32 PM
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