F. Martel, L. Ribeiro, and C. Calhau, Characterization of the efflux of the organic cation MPP+ in cultured rat hepatocytes, Eur J Pharmacol, vol.379, issue.23, pp.211-219, 1999.

F. Martel, C. Calhau, and I. Azevedo, Characterization of the transport of the organic cation [3H]MPP+ in human intestinal epithelial (Caco-2) cells, Naunyn Schmiedebergs Arch Pharmacol, vol.361, issue.5, pp.505-518, 2000.

A. J. Slot, S. V. Molinski, and S. P. Cole, Mammalian multidrug-resistance proteins (MRPs)

, Essays Biochem, vol.50, issue.1, pp.179-207, 2011.

S. P. Cole, Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATPbinding cassette (ABC) transporter, J Biol Chem, vol.289, issue.45, pp.30880-30888, 2014.

D. Keppler, Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy, Handb Exp Pharmacol, vol.2011, pp.299-323

E. V. Malofeeva, N. Domanitskaya, and M. Gudima, Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7)

, Cancer Res, vol.72, issue.24, pp.6457-67, 2012.

P. Pubmed, , 23087055.

T. Oguri, Y. Bessho, and H. Achiwa, MRP8/ABCC11 directly confers resistance to 5fluorouracil. Mol Cancer Ther, vol.6, pp.122-129, 2007.

, , vol.15, pp.53-69

, PubMed Central PMCID: PMC3535093. eng

J. Konig, Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms, Handb Exp Pharmacol, vol.2011, pp.1-28

G. Burckhardt, Drug transport by Organic Anion Transporters (OATs)

. Ther, , vol.136, pp.106-136, 2012.

Y. Nozaki, H. Kusuhara, and T. Kondo, Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices, J Pharmacol Exp Ther, vol.321, issue.1, pp.362-371, 2007.

E. Hodgson and R. L. Rose, Human metabolic interactions of environmental chemicals, J Biochem Mol Toxicol, vol.21, issue.4, pp.182-188, 2007.

K. Abass, V. Lamsa, and P. Reponen, Characterization of human cytochrome P450 induction by pesticides, Toxicology, vol.294, issue.1, pp.17-26, 2012.

X. C. Kretschmer and W. S. Baldwin, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact, vol.155, issue.3, pp.111-139, 2005.

J. L. Staudinger, A. Madan, and K. M. Carol, Regulation of drug transporter gene expression by nuclear receptors, Drug Metab Dispos, vol.31, issue.5, pp.523-530, 2003.
DOI : 10.1124/dmd.31.5.523

URL : http://dmd.aspetjournals.org/content/dmd/31/5/523.full.pdf

A. Geick, M. Eichelbaum, and O. Burk, Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin, ? An interesting review about transporter regulation by nuclear receptors 76, vol.276, pp.14581-14588, 2001.
DOI : 10.1074/jbc.m010173200

URL : http://www.jbc.org/content/276/18/14581.full.pdf

H. R. Kast, B. Goodwin, and P. T. Tarr, Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid Xactivated receptor, and constitutive androstane receptor, J Biol Chem, vol.277, issue.4, pp.2908-2923, 2002.

S. Teng, V. Jekerle, and M. Piquette-miller, Induction of ABCC3 (MRP3) by pregnane X receptor activators, Drug Metab Dispos, vol.31, issue.11, pp.1296-1305, 2003.
DOI : 10.1124/dmd.31.11.1296

URL : http://dmd.aspetjournals.org/content/dmd/31/11/1296.full.pdf

S. K. Whyte-allman, M. T. Hoque, and M. A. Jenabian, Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier, J Pharmacol Exp Ther, 2017.
DOI : 10.1124/jpet.117.243584

, , vol.363, pp.324-335

G. Austin, A. Holcroft, and N. Rinne, Evidence that the pregnane X and retinoid receptors PXR, RAR and RXR may regulate transcription of the transporter hOCT1 in chronic myeloid leukaemia cells, Eur J Haematol, vol.94, issue.1, pp.74-82, 2015.

L. Cerveny, L. Svecova, and E. Anzenbacherova, Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways, Drug Metab Dispos, vol.35, issue.7, pp.1032-1073, 2007.

O. Burk, K. A. Arnold, and A. Geick, A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression, Biol Chem, vol.386, issue.6, pp.503-516, 2005.

X. Wang, D. B. Sykes, and D. S. Miller, Constitutive androstane receptor-mediated upregulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier, Mol Pharmacol, vol.78, issue.3, pp.376-83, 2010.

M. Wagner, E. Halilbasic, and H. U. Marschall, CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

, Hepatology, vol.42, issue.2, pp.420-450, 2005.

M. Ananthanarayanan, N. Balasubramanian, and M. Makishima, Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor

, J Biol Chem, vol.276, issue.31, pp.28857-65, 2001.

G. Lemaire, G. De-sousa, and R. Rahmani, A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides, Biochem Pharmacol, vol.68, issue.12, pp.2347-58, 2004.

W. S. Baldwin and J. A. Roling, A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures, Toxicol Sci, 2009.

, , vol.107, pp.93-105

M. E. Ridano, A. C. Racca, and J. B. Flores-martin, Impact of chlorpyrifos on human villous trophoblasts and chorionic villi, Toxicol Appl Pharmacol, vol.329, pp.26-39, 2017.

L. Zhang, Y. D. Zhang, and J. M. Strong, A regulatory viewpoint on transporter-based drug interactions, Xenobiotica, vol.38, issue.7-8, pp.709-733, 2008.

A. W. Glynn, A. Wolk, and M. Aune, Serum concentrations of organochlorines in men: a search for markers of exposure, Sci Total Environ, vol.263, issue.1-3, pp.197-208, 2000.

, PubMed PMID: 11194153; eng

G. Leng, U. Ranft, and D. Sugiri, Pyrethroids used indoors-biological monitoring of exposure to pyrethroids following an indoor pest control operation, Int J Hyg Environ Health, vol.206, issue.2, pp.85-92, 2003.

L. E. Ruiz-suarez, R. A. Castro-chan, and N. E. Rivero-perez, Levels of organochlorine pesticides in blood plasma from residents of malaria-endemic communities in

M. Chiapas, Int J Environ Res Public Health, vol.11, issue.10, 2014.

M. Gulden, S. Morchel, and S. Tahan, Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology, vol.175, pp.201-214, 2002.

T. S. Mcmullin, J. M. Brzezicki, and B. K. Cranmer, Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine, J Toxicol Environ Health A, vol.66, issue.10, pp.941-64, 2003.

C. L. Lanning, R. L. Fine, and C. W. Sachs, Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein, J Toxicol Environ Health

, , vol.47, pp.395-407

. Eng,

H. Koepsell, Role of organic cation transporters in drug-drug interaction, Expert Opin Drug Metab Toxicol, vol.11, issue.10, pp.1619-1652, 2015.

B. Clarivet, P. Robin, and Y. M. Pers, Tocilizumab and mesenteric arterial thrombosis: drug-drug interaction with anticoagulants metabolized by CYP 450 and/or by Pglycoprotein, Eur J Clin Pharmacol, vol.72, issue.11, pp.1413-1414, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01834388

K. S. Pang, H. J. Maeng, and J. Fan, Interplay of transporters and enzymes in drug and metabolite processing, PubMed PMID, vol.6, issue.6, 2009.

, ? An interesting review about the interplay of transporters and enzymes

T. Murakami and M. Takano, Intestinal efflux transporters and drug absorption, Expert Opin Drug Metab Toxicol, vol.4, issue.7, pp.923-962, 2008.

L. Z. Benet, The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development, J Pharm Sci, vol.102, issue.1, pp.34-42, 2013.

G. L. Hong, J. M. Liu, and G. J. Zhao, Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1, J Cell Biochem, 2016.

, , vol.117, pp.872-80

R. C. Gott, G. R. Kunkel, and E. S. Zobel, Implicating ABC Transporters in Insecticide Resistance: Research Strategies and a Decision Framework, J Econ Entomol, 2017.

, Apr, vol.1, issue.2, pp.667-677

T. H. Niedermeyer, A. Daily, and M. Swiatecka-hagenbruch, Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells

, PubMed PMID: 24614281, PLoS One, vol.9, issue.3, p.91476, 2014.

R. W. Zurawell, H. Chen, and J. M. Burke, Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments, J Toxicol Environ Health B Crit Rev, vol.8, issue.1, pp.1-37, 2005.

H. Tang, D. R. Shen, and Y. H. Han, Development of novel, 384-well high-throughput assay panels for human drug transporters: drug interaction and safety assessment in support of discovery research, J Biomol Screen, vol.18, issue.9, pp.1072-83, 2013.

O. Fardel, L. Vee, M. Jouan, and E. , Nature and uses of fluorescent dyes for drug transporter studies, Expert Opin Drug Metab Toxicol, vol.11, issue.8, pp.1233-51, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01162381

P. Crivori, B. Reinach, and D. Pezzetta, Computational models for identifying potential P-glycoprotein substrates and inhibitors, Mol Pharm, vol.3, issue.1, pp.33-44, 2006.

, PubMed PMID: 16686367; eng

J. M. Pedersen, P. Matsson, and C. A. Bergstrom, Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2), J Med Chem, vol.51, issue.11, pp.3275-87, 2008.

H. Saito, H. Hirano, and H. Nakagawa, A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions, J Pharmacol Exp Ther, 2006.

, PubMed PMID: 16489126; eng, vol.317, pp.1114-1138

E. C. Chen, N. Khuri, and X. Liang, Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1), J Med Chem, 2017.

, Apr, vol.13, issue.7, pp.2685-2696

T. De-bruyn, G. J. Van-westen, and A. P. Ijzerman, Structure-based identification of OATP1B1/3 inhibitors, Mol Pharmacol, vol.83, issue.6, pp.1257-67, 2013.

P. Duan, S. Li, and N. Ai, Potent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterization, Mol Pharm, vol.9, issue.11, pp.3340-3346, 2012.

, PubMed Central PMCID: PMC3490050. eng

L. Chen, Y. Li, and H. Yu, Computational models for predicting substrates or inhibitors of P-glycoprotein, Drug Discov Today, vol.17, issue.7-8, pp.343-51, 2012.

, ? A review about the prediction of P-gp-chemical interactions by computational approaches

A. Daina, O. Michielin, and V. Zoete, SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep, vol.7, p.42717, 2017.

L. Chedik, D. Mias-lucquin, and A. Bruyere, In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans
URL : https://hal.archives-ouvertes.fr/hal-01560242

, Int J Environ Res Public Health, vol.14, issue.7, 2017.

, ? A study using in silico approach for predicting the transport of pesticides across cellular barriers

T. M. Sissung, S. M. Troutman, and T. J. Campbell, Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy

, Discov Med, vol.13, issue.68, pp.19-34, 2012.

S. Ahmed, Z. Zhou, and J. Zhou, Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine, Genomics Proteomics Bioinformatics, vol.14, issue.5, pp.298-313, 2016.

S. Narayan, J. S. Sinsheimer, and K. C. Paul, Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease, Environ Res, vol.143, pp.98-106, 2015.

Q. Zhou, L. S. Yu, and S. Zeng, Stereoselectivity of chiral drug transport: a focus on enantiomer-transporter interaction, Drug Metab Rev, vol.46, issue.3, pp.283-90, 2014.

J. Xu, G. Li, and Z. Wang, The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues, Chemosphere, vol.145, pp.487-94, 2016.

O. Kimura, K. Tsukagoshi, and M. Hayasaka, Transepithelial transport of 4-chloro-2methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers

, Basic Clin Pharmacol Toxicol, vol.110, issue.6, pp.530-536, 2012.

S. Shi and Y. Li, Interplay of Drug-Metabolizing Enzymes and Transporters in Drug Absorption and Disposition, Curr Drug Metab, vol.15, issue.10, pp.915-956, 2014.

C. Lu, C. M. Holbrook, and L. M. Andres, The implications of using a physiologically based pharmacokinetic (PBPK) model for pesticide risk assessment. Environ Health Perspect, PubMed PMID, vol.118, issue.1, pp.125-155, 2010.

J. B. Knaak, C. C. Dary, and X. Zhang, Parameters for pyrethroid insecticide QSAR and PBPK/PD models for human risk assessment, Rev Environ Contam Toxicol, vol.219, pp.1-114, 2012.

, Figure 1. Accumulation of the pyrethroids allethrin and tetramethrin in OCT1-and OCT2transfected HEK293 cells