TOXsIgN a cross-species repository for toxicogenomic signatures

Thomas A. Darde 1 Pierre Gaudriault 2 Rémi Béranger 2 Clement Lancien 2 Annaelle Caillarec-Joly 3 Olivier Sallou 1 Nathalie Bonvallot 2 Cécile Chevrier 2 Severine Mazaud-Guittot 3 Bernard Jégou 2 Olivier Collin 1 Emmanuelle Becker 2 Antoine D. Rolland 2 Frédéric Chalmel 2
1 Plateforme bioinformatique GenOuest [Rennes]
UR1 - Université de Rennes 1, Plateforme Génomique Santé Biogenouest®, Inria Rennes – Bretagne Atlantique , IRISA - Institut de Recherche en Informatique et Systèmes Aléatoires
2 EHESP - École des Hautes Études en Santé Publique [EHESP]
3 Irset - Institut de recherche, santé, environnement et travail
Abstract : Motivation At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given the increasing demand for access to this information, we developed TOXsIgN, a repository for TOXicogenomic sIgNatures. Results The TOXsIgN repository provides a flexible environment that facilitates online submission, storage and retrieval of toxicogenomic signatures by the scientific community. It currently hosts 754 projects that describe more than 450 distinct chemicals and their 8491 associated signatures. It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable signature comparisons or enrichment analyses. Availability and Implementation: The TOXsIgN repository is freely accessible at http://toxsign.genouest.org. Website implemented in Python, JavaScript, and MongoDB, with all major browsers supported.
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IRSET | UNIV-RENNES1 | UNIV-AG | CENTRALESUPELEC | IRSET-8 | IRSET-9 | BIOSIT | IRISA | UR1-UFR-SVE | IRSET-EHESP | INRIA | EHESP | UNIV-ANGERS | UNIV-RENNES | USPC | UR1-UFR-ISTIC | INSA-GROUPE

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Thomas A. Darde, Pierre Gaudriault, Rémi Béranger, Clement Lancien, Annaelle Caillarec-Joly, et al.. TOXsIgN a cross-species repository for toxicogenomic signatures. Bioinformatics, Oxford University Press (OUP), 2018, 34 (12), pp.2116-2122. ⟨10.1093/bioinformatics/bty040⟩. ⟨hal-01863047⟩

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