Perinatal SSRI medications and offspring hippocampal plasticity interaction with maternal stress and sex

Abstract : There is growing use of selective serotonin reuptake inhibitor antidepressant (SSRI) medications during the perinatal period to treat maternal affective disorders. Perinatal SSRI exposure can have a long-term impact on offspring neuroplasticity and behavioral development that remains to be fully elucidated. This mini-review will summarize what is known about the effects of perinatal SSRIs on plasticity in the developing hippocampus, taking into account the role that maternal stress and depression may have. Emerging clinical findings and research in animal models will be discussed. In addition, sexually differentiated effects will be highlighted, as recent work shows that male offspring are often more sensitive to the effects of maternal stress, whereas female offspring can be more sensitive to perinatal SSRIs. Potential mechanisms behind these changes and aims for future research will also be discussed. Understanding the impact of perinatal SSRIs on neuroplasticity will provide better insight into the long-term effects of such medications on the health and well-being of both mother and child and may improve therapeutic approaches for maternal mood disorders during the perinatal period.
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Submitted on : Tuesday, September 18, 2018 - 3:11:48 PM
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Jodi L. Pawluski, Mary Gemmel. Perinatal SSRI medications and offspring hippocampal plasticity interaction with maternal stress and sex. Hormones-International Journal of Endocrinology and Metabolism, 2018, 17 (1), pp.15-24. ⟨10.1007/s42000-018-0011-y⟩. ⟨hal-01863048v2⟩

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