Children's contrast sensitivity function in relation to organophosphate insecticide prenatal exposure in the mother-child PELAGIE cohort

Chloé Cartier 1, 2 Charline Warembourg 1 Christine Monfort 1 Florence Rouget 1, 3 Gwendolina Limon 4 Gaël Durand 4 Sylvaine Cordier 1 Dave Saint-Amour 2, 5, 6, * Cécile Chevrier 1
* Corresponding author
1 Irset - Institut de recherche, santé, environnement et travail
2 Département de Psychologie [Montréal, Québec, Canada]
3 Département de Pédiatrie [CHU Rennes]
4 LABOCEA Laboratoire [Plouzané, France]
5 Centre Hospitalier Universitaire Sainte-Justine [Montréal, Québec, Canada]
6 Département d'Ophtalmologie [Montréal, Québec, Canada]
Abstract : Human exposure to organophosphate pesticides (OP) is widespread. Several studies suggest that OP prenatal exposure alters the development of cognitive and behavioural functions in children, but the effects of OP prenatal exposure on child sensory functions are largely unknown. The aim of the study was to evaluate the association between OP prenatal exposure and visual processing in school-aged children from the mother-child PELAGIE cohort (France). OP biomarkers of exposure were measured in maternal urine samples at the beginning of pregnancy. The Functional Acuity Contrast Test (FACT) was used to assess visual contrast sensitivity in 180 children at 6 years of age. Linear regression models were performed on all children, and separately for boys and girls, taking into account various potential confounders, including maternal education and breastfeeding. No associations were observed in the whole sample, while maternal OP urinary metabolite levels were associated with a decrease of FACT scores in boys. These findings indicate that OP prenatal exposure might impair visual processing later in life in boys only.
Keywords : Contrast sensitivity Vision Development Children Organophosphate insecticides
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UNIV-RENNES | UR1-UFR-SVE | BIOSIT | IRSET | IRSET-9 | UNIV-RENNES1 | PELAGIE | IRSET-EHESP | EHESP | UNIV-ANGERS | USPC

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Chloé Cartier, Charline Warembourg, Christine Monfort, Florence Rouget, Gwendolina Limon, et al.. Children's contrast sensitivity function in relation to organophosphate insecticide prenatal exposure in the mother-child PELAGIE cohort. NeuroToxicology, Elsevier, 2018, 67, pp.161-168. ⟨10.1016/j.neuro.2018.05.004⟩. ⟨hal-01863049v2⟩

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