Children's contrast sensitivity function in relation to organophosphate insecticide prenatal exposure in the mother-child PELAGIE cohort

Abstract : Human exposure to organophosphate pesticides (OP) is widespread. Several studies suggest that OP prenatal exposure alters the development of cognitive and behavioural functions in children, but the effects of OP prenatal exposure on child sensory functions are largely unknown. The aim of the study was to evaluate the association between OP prenatal exposure and visual processing in school-aged children from the mother-child PELAGIE cohort (France). OP biomarkers of exposure were measured in maternal urine samples at the beginning of pregnancy. The Functional Acuity Contrast Test (FACT) was used to assess visual contrast sensitivity in 180 children at 6 years of age. Linear regression models were performed on all children, and separately for boys and girls, taking into account various potential confounders, including maternal education and breastfeeding. No associations were observed in the whole sample, while maternal OP urinary metabolite levels were associated with a decrease of FACT scores in boys. These findings indicate that OP prenatal exposure might impair visual processing later in life in boys only.
Complete list of metadatas

Cited literature [58 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01863049
Contributor : Laurent Jonchère <>
Submitted on : Thursday, September 6, 2018 - 1:20:57 PM
Last modification on : Wednesday, August 14, 2019 - 2:18:05 PM

File

Cartier et al_2018_Children’...
Files produced by the author(s)

Identifiers

Citation

Chloé Cartier, Charline Warembourg, Christine Monfort, Florence Rouget, Gwendolina Limon, et al.. Children's contrast sensitivity function in relation to organophosphate insecticide prenatal exposure in the mother-child PELAGIE cohort. NeuroToxicology, Elsevier, 2018, 67, pp.161-168. ⟨10.1016/j.neuro.2018.05.004⟩. ⟨hal-01863049v2⟩

Share

Metrics

Record views

219

Files downloads

105