Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)

Bendik C. Brinchmann (1, 2) , Tonje Skuland (1) , Mia H. Rambol (3) , Krisztina Szoke (3) , Jan E. Brinchmann (3) , Arno C. Gutleb (4) , Elisa Moschini (4) , Alena Kubátová (5) , Klara Kukowski (5) , E. Le Ferrec (6, 7) , Dominique Lagadic-Gossmann (6, 7) , Per E. Schwarze (1) , Marit Lag (1) , Magne Refsnes (1) , Johan Øvrevik (1) , Jorn A. Holme (1)

1 Department of Air Pollution and Noise, Domain of Infection Control, Environment and Health [Oslo, Norway]
2 Faculty of Medicine - Division of Laboratory Medicine [Oslo, Norway]
3 Norwegian Center for Stem Cell Research - Department of Immunology
4 LIST - Luxembourg Institute of Science and Technology
5 UND - University of North Dakota [Grand Forks]
6 Irset - Institut de recherche en santé, environnement et travail
7 UR Pharmacie - Université de Rennes - Faculté des sciences pharmaceutiques et biologiques

Keywords: Organic compounds; 3D tri-culture; Aryl hydrocarbon receptor; Air pollution; Diesel exhaust particles; Inflammation; Cardiovascular disease; Atherosclerosis; Endothelial cells

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie

Bendik C. Brinchmann, Tonje Skuland, Mia H. Rambol, Krisztina Szoke, Jan E. Brinchmann, et al.. Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Particle and Fibre Toxicology, 2018, 15 (1), pp.21. ⟨10.1186/s12989-018-0257-1⟩. ⟨hal-01863051⟩