Is cancer incidence different between type 2 diabetes patients compared to non-diabetics in hemodialysis? A study from the REIN registry - Archive ouverte HAL Access content directly
Journal Articles Néphrologie & Thérapeutique Year : 2018

Is cancer incidence different between type 2 diabetes patients compared to non-diabetics in hemodialysis? A study from the REIN registry

Patients en hémodialyse : l’incidence de cancer est-elle différente entre les diabétiques de type 2 comparés aux non-diabétiques ? Une étude du registre REIN

, (1, 2) , , , , (3) , (3) , (4) , , , , (5) , (5) , , , (5) , (5) , (1) , (2)
1
2
3
4
5
Aurelie Le Guillou
  • Function : Author
Wahida Kihal
Muriel Siebert
  • Function : Author
Atman Haddj-Elmrabet
  • Function : Author
Anne Bernard
Lise Mandart
  • Function : Author
Didier Hamel
  • Function : Author
Tugdual Tanquerel
  • Function : Author
Bernard Strullu
  • Function : Author
Christine Richer
  • Function : Author
Pascale Siohan
  • Function : Author
Theophile Sawadogo
  • Function : Author
Juliette Baleynaud
  • Function : Author
Simona Baluta
  • Function : Author
Sahar Bayat

Abstract

Background and objectives In France, diabetes mellitus is now the second cause of end stage renal disease. In a large previous French national study, we observed that dialyzed diabetics have a significant lower risk of death by cancer. This first study was focused on cancer death but did not investigate cancer incidence. In this context, the aim of this second study was to compare the incidence of cancer in diabetic dialyzed patients compared to non-diabetic dialyzed patients in a French region. Methods This epidemiologic multicentric study included 588 diabetic and non-diabetic patients starting hemodialysis between 2002 and 2007 in Bretagne. Data were issued from REIN registry and cancer incidence were individually collected from medical records. Diabetics and non-diabetics were matched one by one on age, sex and year of dialysis initiation. ResultsDuring the follow-up, we observed 28 cancers (9.4%) in diabetic patients and 26 cancers (8.9%) in non-diabetics patients. The cumulative incidence to develop a cancer 2 years after the dialysis start was approximately 6% in both diabetics and non-diabetics patients. In univariate Fine and Gray analysis, BMI, hemoglobin, statin use had P-value<0.2. However, in the adjusted model, these variables were not significantly associated with cancer incidence. Conclusion This study lead on a little number of dialyzed patients did not show any significant difference on cancer incidence between diabetic and non-diabetic patients after hemodialysis start.
Not file

Dates and versions

hal-01863212 , version 1 (28-08-2018)

Identifiers

Cite

Aurelie Le Guillou, Adélaide Pladys, Wahida Kihal, Muriel Siebert, Atman Haddj-Elmrabet, et al.. Patients en hémodialyse : l’incidence de cancer est-elle différente entre les diabétiques de type 2 comparés aux non-diabétiques ? Une étude du registre REIN. Néphrologie & Thérapeutique, 2018, 14 (3), pp.142-147. ⟨10.1016/j.nephro.2017.02.018⟩. ⟨hal-01863212⟩
52 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More