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Patients en hémodialyse : l’incidence de cancer est-elle différente entre les diabétiques de type 2 comparés aux non-diabétiques ? Une étude du registre REIN

Aurelie Le Guillou Adélaide Pladys 1, 2 Wahida Kihal Muriel Siebert Atman Haddj-Elmrabet Charlotte Cernon 3 Anne Bernard 3 Christoph E. Charasse 4 Lise Mandart Didier Hamel Tugdual Tanquerel Bernard Strullu 5 Christine Richer 5 Pascale Siohan Theophile Sawadogo Juliette Baleynaud 5 Simona Baluta 5 Sahar Bayat 1 Cécile Vigneau 2
1 EHESP - École des Hautes Études en Santé Publique [EHESP]
2 IGDR - Institut de Génétique et Développement de Rennes
3 CHU Pontchaillou [Rennes]
4 CHU de Saint-Brieuc
5 AUB Santé
Abstract : Background and objectives In France, diabetes mellitus is now the second cause of end stage renal disease. In a large previous French national study, we observed that dialyzed diabetics have a significant lower risk of death by cancer. This first study was focused on cancer death but did not investigate cancer incidence. In this context, the aim of this second study was to compare the incidence of cancer in diabetic dialyzed patients compared to non-diabetic dialyzed patients in a French region. Methods This epidemiologic multicentric study included 588 diabetic and non-diabetic patients starting hemodialysis between 2002 and 2007 in Bretagne. Data were issued from REIN registry and cancer incidence were individually collected from medical records. Diabetics and non-diabetics were matched one by one on age, sex and year of dialysis initiation. Results During the follow-up, we observed 28 cancers (9.4%) in diabetic patients and 26 cancers (8.9%) in non-diabetics patients. The cumulative incidence to develop a cancer 2 years after the dialysis start was approximately 6% in both diabetics and non-diabetics patients. In univariate Fine and Gray analysis, BMI, hemoglobin, statin use had P-value<0.2. However, in the adjusted model, these variables were not significantly associated with cancer incidence. Conclusion This study lead on a little number of dialyzed patients did not show any significant difference on cancer incidence between diabetic and non-diabetic patients after hemodialysis start.
Mots-clés : Diabetes Cancer End stage renal disease Hemodialysis Mortality risk
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01863212
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, August 28, 2018 - 11:15:45 AM
Last modification on : Thursday, January 14, 2021 - 11:22:31 AM

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UNIV-RENNES1 | IGDR | CNRS | BIOSIT | UR1-UFR-SVE | EHESP | UNIV-RENNES | USPC | METIS-EHESP | MOS | REPERES

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Aurelie Le Guillou, Adélaide Pladys, Wahida Kihal, Muriel Siebert, Atman Haddj-Elmrabet, et al.. Patients en hémodialyse : l’incidence de cancer est-elle différente entre les diabétiques de type 2 comparés aux non-diabétiques ? Une étude du registre REIN. Néphrologie et Thérapeutique, Elsevier Masson, 2018, 14 (3), pp.142-147. ⟨10.1016/j.nephro.2017.02.018⟩. ⟨hal-01863212⟩

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