Causes of genome instability, Annu Rev Genet, vol.47, pp.1-32, 2013. ,
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells, Nat Commun, vol.7, p.10660, 2016. ,
Unprotected replication forks are converted into mitotic sister chromatid bridges, Mol Cell, vol.66, pp.398-410, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02331509
Replication in hydroxyurea: It's a matter of time, Mol Cell Biol, vol.27, pp.6396-6406, 2007. ,
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe, Yeast, vol.14, pp.943-951, 1998. ,
Synergistic actions of Rad51 and Rad52 in recombination and DNA repair, Nature, vol.391, pp.401-404, 1998. ,
Nucleotide deficiency promotes genomic instability in early stages of cancer development, Cell, vol.145, pp.435-446, 2011. ,
ATR disruption leads to chromosomal fragmentation and early embryonic lethality, Genes Dev, vol.14, pp.397-402, 2000. ,
Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes, Genome Res, vol.20, pp.447-457, 2010. ,
URL : https://hal.archives-ouvertes.fr/ensl-00517756
Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells, EMBO J, vol.31, pp.3678-3690, 2012. ,
DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI, J Mol Biol, vol.375, pp.12-19, 2008. ,
A global profile of replicative polymerase usage, Nat Struct Mol Biol, vol.22, pp.192-198, 2015. ,
Fragile genomic sites are associated with origins of replication, Genome Biol Evol, vol.1, pp.350-363, 2009. ,
Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis, Nat Cell Biol, vol.2, pp.686-694, 2000. ,
DNA replication timing, genome stability and cancer: Late and/or delayed DNA replication timing is associated with increased genomic instability, Semin Cancer Biol, vol.23, pp.80-89, 2013. ,
ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset, Cell Rep, vol.5, pp.1095-1107, 2013. ,
Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication, Nat Cell Biol, vol.8, pp.148-155, 2006. ,
Replication stressinduced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation, G3 (Bethesda), vol.1, pp.327-335, 2011. ,
Basic methods for fission yeast, Yeast, vol.23, pp.173-183, 2006. ,
Nuclear architecture organized by Rif1 underpins the replication-timing program, Mol Cell, vol.61, pp.260-273, 2016. ,
DNA replication origin activation in space and time, Nat Rev Mol Cell Biol, vol.16, pp.360-374, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01159618
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories, J Cell Biol, vol.191, pp.1285-1297, 2010. ,
Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome, PLoS Genet, vol.5, p.1000485, 2009. ,
Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding, Mol Biol Cell, vol.14, pp.3876-3887, 2003. ,
Cellular regulation of ribonucleotide reductase in eukaryotes, Semin Cell Dev Biol, vol.30, pp.97-103, 2014. ,
An oncogene-induced DNA damage model for cancer development, Science, vol.319, pp.1352-1355, 2008. ,
Rif1 is a global regulator of timing of replication origin firing in fission yeast, Genes Dev, vol.26, pp.137-150, 2012. ,
Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast, EMBO J, vol.26, pp.1327-1339, 2007. ,
Genetics of the fission yeast Schizosaccharomyces pombe, Annu Rev Genet, vol.26, pp.373-402, 1992. ,
Genome-wide characterization of fission yeast DNA replication origins, EMBO J, vol.25, pp.5171-5179, 2006. ,
The NDA3 gene of fission yeast encodes ?-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis, Cell, vol.39, pp.349-358, 1984. ,
Global reorganization of replication domains during embryonic stem cell differentiation, PLoS Biol, vol.6, p.245, 2008. ,
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis, Genome Res, vol.20, pp.155-169, 2010. ,
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli, Gene, vol.57, pp.267-272, 1987. ,
Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription, Genome Res, vol.25, pp.402-412, 2015. ,
The effect of the intra-S-phase checkpoint on origins of replication in human cells, Genes Dev, vol.25, pp.621-633, 2011. ,
The spatial and temporal organization of origin firing during the S-phase of fission yeast, Genome Res, vol.25, pp.391-401, 2015. ,
Differential relationship of DNA replication timing to different forms of human mutation and variation, Am J Hum Genet, vol.91, pp.1033-1040, 2012. ,
Surviving chromosome replication: the many roles of the S-phase checkpoint pathway, Philos Trans R Soc B Biol Sci, vol.366, pp.3554-3561, 2011. ,
Chk1 is haploinsufficient for multiple functions critical to tumor suppression, Cancer Cell, vol.6, pp.45-59, 2004. ,
Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange, Mol Cell, vol.39, pp.346-359, 2010. ,
Mutation rates across budding yeast chromosome VI are correlated with replication timing, Genome Biol Evol, vol.3, pp.799-811, 2011. ,
Rad52 forms DNA repair and recombination centers during S phase, Proc Natl Acad Sci, vol.98, pp.8276-8282, 2001. ,
DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes, Nat Commun, vol.4, p.1502, 2013. ,
Damage-induced phosphorylation of Sld3 is important to block late origin firing, Nature, vol.467, pp.479-483, 2010. ,
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast, EMBO J, vol.30, pp.4805-4814, 2011. ,
The temporal program of chromosome replication: genomewide replication in clb5? Saccharomyces cerevisiae, Genetics, vol.180, pp.1833-1847, 2008. ,
Checkpoint independence of most DNA replication origins in fission yeast, BMC Mol Biol, vol.8, p.112, 2007. ,
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe, Methods Enzymol, vol.194, pp.795-823, 1991. ,
Conservation of replication timing reveals global and local regulation of replication origin activity, Genome Res, vol.22, pp.1953-1962, 2012. ,
DNA replication origins fire stochastically in fission yeast, Mol Biol Cell, vol.17, pp.308-316, 2006. ,
dNTP pools determine fork progression and origin usage under replication stress, EMBO J, vol.31, pp.883-894, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00677221
DNA replication timing, Cold Spring Harb Perspect Biol, vol.5, p.10132, 2013. ,
Replicating large genomes: divide and conquer, Mol Cell, vol.62, pp.756-765, 2016. ,
Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells, Genome Res, vol.25, pp.1091-1103, 2015. ,
RStudio: integrated development for, 2015. ,
Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types, Genome Res, vol.20, pp.761-770, 2010. ,
A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication, Nature, vol.395, pp.615-618, 1998. ,
ATR and ATM regulate the timing of DNA replication origin firing, Nat Cell Biol, vol.6, pp.648-655, 2004. ,
Regulation of DNA-replication origins during cell-cycle progression, Nature, vol.395, pp.618-621, 1998. ,
Human mutation rate associated with DNA replication timing, Nat Genet, vol.41, pp.393-395, 2009. ,
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage, Mol Cell Biol, vol.25, pp.3553-3562, 2005. ,
Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair, Microbiol Mol Biol Rev, vol.66, pp.630-670, 2002. ,
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast, EMBO J, vol.30, pp.2019-2030, 2011. ,
Rad4 TopBP1 , a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication, Mol Biol Cell, vol.17, pp.3456-3468, 2006. ,
ATR prohibits replication catastrophe by preventing global exhaustion of RPA, Cell, vol.155, pp.1088-1103, 2013. ,
Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification, Nucleic Acids Res, vol.36, p.21, 2008. ,
Binding of double-strand breaks in DNA by human Rad52 protein, Nature, vol.398, pp.728-731, 1999. ,
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism, Annu Rev Biochem, vol.66, pp.61-92, 1997. ,
Establishing the program of origin firing during S phase in fission yeast, Cell, vol.136, pp.852-864, 2009. ,
Replication origin selection regulates the distribution of meiotic recombination, Mol Cell, vol.53, pp.655-662, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01010761
Rif1 regulates the replication timing domains on the human genome, EMBO J, vol.31, pp.3667-3677, 2012. ,
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation, Nature, vol.467, pp.474-478, 2010. ,
Causes and consequences of replication stress, Nat Cell Biol, vol.16, pp.2-9, 2014. ,
Mapping genomic hotspots of DNA damage by a single-strandDNA-compatible and strand-specific ChIP-seq method, Genome Res, vol.23, pp.705-715, 2013. ,