Time-dependent effect of intensity of smoking and of occupational exposure to asbestos on the risk of lung cancer results from the ICARE case-control study

Emilie Lévêque 1 Aude Lacourt 1 Danièle Luce 2, 3 Marie-Pierre Sylvestre 4 Pascal Guénel 5 Isabelle Stücker 5 Karen Leffondré 1
1 LBMA - Laboratoire de Biotechnologie et Microbiologie Appliquée
2 Irset - Institut de recherche, santé, environnement et travail
3 EHESP - École des Hautes Études en Santé Publique [EHESP]
4 Université de Montréal [Montréal]
5 CESP - Centre de recherche en épidémiologie et santé des populations
Abstract : Objective - To estimate the impact of intensity of both smoking and occupational exposure to asbestos on the risk of lung cancer throughout the whole exposure history. Methods - Data on 2026 male cases and 2610 male controls came from the French ICARE (Investigation of occupational and environmental causes of respiratory cancers) population-based, case-control study. Lifetime smoking history and occupational history were collected from standardised questionnaires and face-to-face interviews. Occupational exposure to asbestos was assessed using a job exposure matrix. The effects of annual average daily intensity of smoking (reported average number of cigarettes smoked per day) and asbestos exposure (estimated average daily air concentration of asbestos fibres at work) were estimated using a flexible weighted cumulative index of exposure in logistic regression models. Results - Intensity of smoking in the 10 years preceding diagnosis had a much stronger association with the risk of lung cancer than more distant intensity. By contrast, intensity of asbestos exposure that occurred more than 40 years before diagnosis had a stronger association with the risk of lung cancer than more recent intensity, even if intensity in the 10 years preceding diagnosis also had a significant effect. Conclusion - Our results illustrate the dynamic of the effect of intensity of both smoking and occupational exposure to asbestos on the risk of lung cancer. They confirm that the timing of exposure plays an important role, and suggest that standard analytical methods assuming equal weights of intensity over the whole exposure history may be questionable.
Keywords : dose-time-response relationship latency age-dependent susceptibility asbestos case-control study exposure intensity lung cancer smoking men
Document type :
Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01863276
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, August 28, 2018 - 11:42:48 AM
Last modification on : Thursday, July 11, 2019 - 1:02:04 AM

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Emilie Lévêque, Aude Lacourt, Danièle Luce, Marie-Pierre Sylvestre, Pascal Guénel, et al.. Time-dependent effect of intensity of smoking and of occupational exposure to asbestos on the risk of lung cancer results from the ICARE case-control study. Occupational and Environmental Medicine, BMJ Publishing Group, 2018, 75 (8), pp.586-592. ⟨10.1136/oemed-2017-104953⟩. ⟨hal-01863276⟩

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