IGHV segment utilization in immunoglobulin gene rearrangement differentiates patients with anti-myelin-associated glycoprotein neuropathy from others immunoglobulin M-gammopathies

Jean-Sebastien Allain (1) , Florian Thonier (2) , Morgane Pihan (3) , Marie-Laure Boulland (2) , Sophie de Guibert (4) , Vincent Launay (5) , Anne-Violaine Doncker (6) , Michel Ganard (4, 7) , Amyra Aliouat (8) , Céline Pangault (9, 2, 7) , Roch Houot (9, 7, 4) , Marie de Tayrac (8, 7) , Thierry Lamy (9, 7, 4) , Mikael Roussel (9, 2) , Thierry Fest (9, 2, 7) , Olivier Decaux (9, 7, 1) , Cedric Pastoret (9, 2, 7)

1 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
2 CHU Pontchaillou [Rennes]
3 Service de Neurologie [Rennes] = Neurology [Rennes]
4 Service d’Hématologie Clinique [Rennes]
5 Service d’Hématologie [CH Saint Brieuc]
6 Hopital Privé Sévigné [Cesson-Sévigné, France]
7 UR1 - Université de Rennes 1
8 Pôle de Biologie - Laboratoire de Bioinformatique Médicale [CHU Rennes]
9 MICMAC - Microenvironment, Cell Differentiation, Immunology and Cancer

no abstract.

Keywords: immunoglobulin gene; High throughput sequencing; Monoclonal Gammopathy of Undetermined Significance; Waldenström Macroglobulinemia; MYD88; CXCR4; anti-MAG

Domains: Life Sciences [q-bio]; Genetics; Human genetics; Life Sciences [q-bio]; Immunology

Jean-Sebastien Allain, Florian Thonier, Morgane Pihan, Marie-Laure Boulland, Sophie de Guibert, et al.. IGHV segment utilization in immunoglobulin gene rearrangement differentiates patients with anti-myelin-associated glycoprotein neuropathy from others immunoglobulin M-gammopathies. Haematologica, 2018, 103 (5), pp.e207-e210. ⟨10.3324/haematol.2017.177444⟩. ⟨hal-01863385⟩