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Serum CXCL10, CXCL11, CXCL12, and CXCL14 chemokine patterns in patients with acute liver injury

Abstract : The chemokines CXCL10 (interferon ϒ-inducible protein 10 [IP-10]), CXCL11 (Human interferon inducible T cell alpha chemokine [I-TAC]), CXCL12 (stromal cell derived factor 1 [SDF-1]), and CXCL14 (breast and kidney-expressed chemokine [BRAK]) are involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. However, their expression in patients with acute liver injury is unknown. Here, we aimed to provide evidence of the presence of circulating CXCL10, CXCL11, CXCL12, and CXCL14 during human acute liver injury to propose new inflammation biomarkers for acute liver injury.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01863796
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Submitted on : Monday, September 3, 2018 - 2:10:35 PM
Last modification on : Wednesday, October 20, 2021 - 3:19:22 AM
Long-term archiving on: : Tuesday, December 4, 2018 - 2:54:29 PM

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Arnaud Chalin, Benjamin Lefèvre, Christelle Devisme, Charlotte Pronier, Virginie Carrière, et al.. Serum CXCL10, CXCL11, CXCL12, and CXCL14 chemokine patterns in patients with acute liver injury. Cytokine, In press, ⟨10.1016/j.cyto.2018.05.029⟩. ⟨hal-01863796v1⟩

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