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Treatment plans and outcomes in elderly patients reaching advanced chronic kidney disease

Olivier Moranne 1, 2 Coraline Fafin Sophie Roche Maud Francois Vincent Allot 3 Jerome Potier 4 Daniela Babici Thierry Lobbedez 5 Marie Matignon 6 Christophe Mariat 7 Cécile Vigneau 8, 9 Cécile Couchoud 10, 11
1 AIDMP - Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415
2 CHRU Nîmes - Centre Hospitalier Régional Universitaire de Nîmes
3 Service de Néphrologie, Dialyse, Transplantations [CHU Limoges]
4 CH de Saint-Brieuc
5 CHU Caen
6 Service de Néphrologie Dialyse Transplantation, CHU Ibn Rochd, Casablanca
7 CHU Saint-Etienne
8 CHU Pontchaillou [Rennes]
9 Irset - Institut de recherche en santé, environnement et travail
10 Registre REIN [Saint-Denis La Plaine, France]
11 Biostatistiques santé
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
Abstract : Background - Elderly patients with advanced chronic kidney disease require accurate outcome descriptions to make treatment decisions. Methods - The PSPA [Parcours de soins des personnes âgées (Treatment pathways for elderly patients)] prospective multicentre cohort study included 573 such patients with a median age of 82 [interquartile range (IQR) 79-86] years and a median estimated glomerular filtration rate of 14 (IQR 11-17) mL/min/1.73 m2 and studied their 5-year outcomes according to the dialysis component of their treatment plans. Results - Mean follow-up for the overall cohort was 34.5 ± 21 months and the 5-year survival rate was 27%. During follow-up, 288 (50%) patients started dialysis and 237 (42%) died before dialysis. At baseline, the four possible dialysis plans were dialysis when needed (38%), stable without mention of a dialysis plan (40%) and dialysis specifically excluded by the patient's (9%) or nephrologist's decision (12%). These baseline plans were associated with death and dialysis start. Follow-up plans were those decided during the study period: dialysis when needed for 47%, stable without mention of a dialysis plan for 20% and dialysis excluded at any time for 32%. For the subgroup of patients who started dialysis, those whose follow-up plan was dialysis started under better conditions than those who had stable or no dialysis follow-up plans before starting. However, survival afterwards did not differ significantly. Conclusions - These findings indicate that nephrology care should accommodate changes over time in older patients' treatment preferences and plans concerning dialysis. These changes are associated with whether, when and how these patients initiate dialysis but are not necessarily associated with post-dialysis survival.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01863801
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, August 29, 2018 - 9:56:03 AM
Last modification on : Monday, February 10, 2020 - 4:36:57 PM

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UNIV-RENNES1 | IRSET | CNRS | BIOENVIS | IRSET-8 | UNIV-LYON1 | BIOSIT | UR1-UFR-SVE | MIPS | INRIA | UNIV-MONTPELLIER | UNIV-ANGERS | UNIV-RENNES | COMUE-NORMANDIE | UDL

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Olivier Moranne, Coraline Fafin, Sophie Roche, Maud Francois, Vincent Allot, et al.. Treatment plans and outcomes in elderly patients reaching advanced chronic kidney disease. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2018, 33 (12), pp.2182-2191. ⟨10.1093/ndt/gfy046⟩. ⟨hal-01863801⟩

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