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Regulatory identification of BPA as an endocrine disruptor : Context and methodology

Claire Beausoleil 1 Claude Emond 2 Jean-Pierre Cravedi 3 Jean-Philippe Antignac 4 Martine Applanat 5 Brice R. Appenzeller 6 Remy Beaudouin 7 L P Belzunces 8, 9 Marie-Chantal Canivenc Lavier 10, 11 Nicolas Chevalier 12 Cécile Chevrier 13, 14 Elisabeth Elefant 15 Florence Eustache 16 René Habert 17 Martine Kolf-Clauw 18 Brigitte Le Magueresse-Battistoni 19 Sakina Mhaouty-Kodja 20 C Minier 7 Luc Multigner 13, 14 Henri Schroeder 21 P Thonneau 22 Catherine Viguié 23 François Pouzaud 1 Jean-Nicolas Ormsby 1 Christophe Rousselle 1 Lauranne Verines-Jouin 1 Elodie Pasquier 1, * Cécile Michel 1
* Corresponding author
18 ANEXPLO
IPBS - Institut de pharmacologie et de biologie structurale, CREFRE - Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales, GENOTOUL - Génopole Toulouse Midi-Pyrénées [Auzeville]
Abstract : BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies, the analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01864338
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Submitted on : Tuesday, September 18, 2018 - 9:34:10 AM
Last modification on : Tuesday, January 25, 2022 - 6:56:07 PM
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Claire Beausoleil, Claude Emond, Jean-Pierre Cravedi, Jean-Philippe Antignac, Martine Applanat, et al.. Regulatory identification of BPA as an endocrine disruptor : Context and methodology. Molecular and Cellular Endocrinology, Elsevier, 2018, 475, pp.4-9. ⟨10.1016/j.mce.2018.02.001⟩. ⟨hal-01864338⟩

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