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Regulatory identification of BPA as an endocrine disruptor : Context and methodology

C Beausoleil 1 C Emond 2 Jean Pierre Cravedi 3 J P Antignac 4 M Applanat 5 B M R Appenzeller 6 R Beaudouin 7 L P Belzunces 8 Marie-Chantal Canivenc Lavier 9, 10 N Chevalier 11 C Chevrier 12, 13 E Elefant 14 F Eustache 15 R Habert 16 Martine Kolf-Clauw 17 Brigitte Le Magueresse-Battistoni 18 Sakina Mhaouty-Kodja 19 C Minier 7 Luc Multigner 12, 13 H Schroeder 20 P Thonneau 21 Catherine Viguié 22 F Pouzaud 1 J N Ormsby 1 C Rousselle 1 L Verines-Jouin 1 E Pasquier 1, * C Michel 1
* Corresponding author
17 ANEXPLO
GENOTOUL - Génopole Toulouse Midi-Pyrénées [Auzeville], CREFRE - Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales, IPBS - Institut de pharmacologie et de biologie structurale
Abstract : BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies, the analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.
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Submitted on : Tuesday, September 18, 2018 - 9:34:10 AM
Last modification on : Tuesday, July 13, 2021 - 3:50:30 AM
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C Beausoleil, C Emond, Jean Pierre Cravedi, J P Antignac, M Applanat, et al.. Regulatory identification of BPA as an endocrine disruptor : Context and methodology. Molecular and Cellular Endocrinology, Elsevier, 2018, 475, pp.4-9. ⟨10.1016/j.mce.2018.02.001⟩. ⟨hal-01864338⟩

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