New transcriptomic tools to understand testis development and functions

Estelle Lecluze 1 Bernard Jégou 1 Antoine D. Rolland 1 Frédéric Chalmel 1
1 Irset - Institut de recherche, santé, environnement et travail
Abstract : The testis plays a central role in the male reproductive system - secreting several hormones including male steroids and producing male gametes. A complex and coordinated molecular program is required for the proper differentiation of testicular cell types and maintenance of their functions in adulthood. The testicular transcriptome displays the highest levels of complexity and specificity across all tissues in a wide range of species. Many studies have used high-throughput sequencing technologies to define the molecular dynamics and regulatory networks in the testis as well as to identify novel genes or gene isoforms expressed in this organ. This review intends to highlight the complementarity of these transcriptomic studies and to show how the use of different sequencing protocols contribute to improve our global understanding of testicular biology.
Keywords : Transcriptomics Testis Development Germ cells RNA-sequencing Spermatogenesis
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Estelle Lecluze, Bernard Jégou, Antoine D. Rolland, Frédéric Chalmel. New transcriptomic tools to understand testis development and functions. Molecular and Cellular Endocrinology, Elsevier, 2018, 468, pp.47-59. ⟨10.1016/j.mce.2018.02.019⟩. ⟨hal-01864339⟩

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