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Characterisation and functional predictions of canine long non-coding RNAs

Abstract : Long non-coding RNAs (lncRNAs) are a family of heterogeneous RNAs that play major roles in multiple biological processes. We recently identified an extended repertoire of more than 10,000 lncRNAs of the domestic dog however, predicting their biological functionality remains challenging. In this study, we have characterised the expression profiles of 10,444 canine lncRNAs in 26 distinct tissue types, representing various anatomical systems. We showed that lncRNA expressions are mainly clustered by tissue type and we highlighted that 44% of canine lncRNAs are expressed in a tissue-specific manner. We further demonstrated that tissue-specificity correlates with specific families of canine transposable elements. In addition, we identified more than 900 conserved dog-human lncRNAs for which we show their overall reproducible expression patterns between dog and human through comparative transcriptomics. Finally, co-expression analyses of lncRNA and neighbouring protein-coding genes identified more than 3,400 canine lncRNAs, suggesting that functional roles of these lncRNAs act as regulatory elements. Altogether, this genomic and transcriptomic integrative study of lncRNAs constitutes a major resource to investigate genotype to phenotype relationships and biomedical research in the dog species.
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Contributor : Xavier Chard-Hutchinson Connect in order to contact the contributor
Submitted on : Thursday, December 13, 2018 - 8:05:41 PM
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Celine Le Beguec, Valentin Wucher, Laetitia Lagoutte, Edouard Cadieul, Nadine Botherel, et al.. Characterisation and functional predictions of canine long non-coding RNAs. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.13444. ⟨10.1038/s41598-018-31770-2⟩. ⟨hal-01888670⟩



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