Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders

Abstract : Several studies have reported an association between the farnesoid X receptor alpha (FXRα) and estrogenic signaling pathways. Fxrα could thus be involved in the reprotoxic effects of endocrine disruptors such as bisphenol-A (BPA). To test this hypothesis, mice were exposed to BPA and/or stigmasterol (S), an FXRα antagonist. Following the exposure to both molecules, wild-type animals showed impaired fertility and lower sperm cell production associated with the alteration of the establishment and maintenance of the undifferentiated germ cell pool. The crosstalk between BPA and FXRα is further supported by the lower impact of BPA in mice genetically ablated for Fxrα and the fact that BPA counteracted the effects of FXRα agonists. These effects might result from the downregulation of Fxrα expression following BPA exposure. BPA and S act additively in human testis. Our data demonstrate that FXRα activity modulates the impact of BPA on male gonads and on undifferentiated germ cell population.
Complete list of metadatas

Cited literature [46 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01888869
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Friday, November 9, 2018 - 9:10:49 AM
Last modification on : Wednesday, July 17, 2019 - 11:44:39 PM
Long-term archiving on : Sunday, February 10, 2019 - 1:01:29 PM

File

Sedes_Crosstalk between BPA.pd...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Lauriane Sèdes, Christele Desdoits-Lethimonier, Betty Rouaisnel, Hélène Holota, Laura Thirouard, et al.. Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders. Stem Cell Reports, Elsevier, 2018, 11 (4), pp.944-958. ⟨10.1016/j.stemcr.2018.08.018⟩. ⟨hal-01888869⟩

Share

Metrics

Record views

156

Files downloads

110