Opposite effects of genistein on the regulation of insulin-mediated glucose homeostasis in adipose tissue, Br J Pharmacol, vol.170, issue.2, p.23763311, 2013. ,
Consumption of soybean, soy foods, soy isoflavones and breast cancer incidence: Differences between Chinese women and women in Western countries and possible mechanisms, Food Science and Human Wellness, 2013. ,
, , vol.2, pp.146-161
Role of phytoestrogens in prevention and management of type 2 diabetes, World J Diabetes, 2015. ,
, , vol.6, pp.271-283
Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes, Curr Diabetes Rev, vol.9, issue.1, p.22974359, 2013. ,
New and emerging drugs and targets for type 2 diabetes: reviewing the evidence, Am Health Drug Benefits, vol.7, issue.8, p.25558307, 2014. ,
Genistein: a promising therapeutic agent for obesity and diabetes treatment, Eur J Pharmacol, vol.698, issue.1-3, p.23178528, 2013. ,
Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic b-cell function, Food Funct, vol.4, issue.2, p.23160185, 2013. ,
Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice, vol.151, p.20484465, 2010. ,
Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells, Eur J Pharmacol, vol.616, issue.1-3, p.19540219, 2009. ,
Genistein protects against Ab induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers, BMC Neurosci, vol.18, issue.1, p.28081713, 2017. ,
Involvement of Ca2+/calmodulin kinase II (CaMK II) in genistein-induced potentiation of leucine/glutamine-stimulated insulin secretion, Mol Cells, vol.28, issue.3, pp.167-174, 2009. ,
Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway, Diabetes, vol.55, issue.4, p.16567527, 2006. ,
Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives, Molecules, vol.21, issue.1, p.26703550, 2015. ,
,
, ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol, 2018.
Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs, Biochemistry, vol.43, issue.9, p.14992594, 2004. ,
Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration, Hum Reprod, vol.22, issue.10, p.17725991, 2007. ,
Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERa expression and induction of apoptosis, Exp Ther Med, vol.8, issue.2, p.25009600, 2014. ,
Genistein inhibits rat aortic smooth muscle cell proliferation through the induction of p27kip1, J Pharmacol Sci, vol.107, issue.1, p.18490856, 2008. ,
Genistein inhibits cell proliferation and stimulates apoptosis in human coronary artery endothelial cells, Gynecol Obstet Invest, vol.75, issue.4, p.23594697, 2013. ,
Genistein modulates prostate epithelial cell proliferation via estrogen-and extracellular signal-regulated kinase-dependent pathways, J Nutr Biochem, vol.17, issue.3, p.16198100, 2006. ,
Genistein Induces Apoptosis and Inhibits Proliferation of HT29 Colon Cancer Cells, Int J Mol Cell Med, vol.5, issue.3, p.27942504, 2016. ,
Protein measurement with the Folin phenol reagent, J Biol Chem, vol.193, issue.1, p.14907713, 1951. ,
10-3H]myristic acids for the detection of defects of fatty acid oxidation in intact cultured fibroblasts, J Inherit Metab Dis, vol.9, issue.1, p.2109149, 1990. ,
Soy isoflavones and cardiovascular disease epidemiological, clinical and -omics perspectives, Curr Pharm Biotechnol, vol.13, issue.5, p.22122477, 2012. ,
Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease, Nutrients, vol.9, issue.4, p.28338639, 2017. ,
Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism, Diabetes, vol.57, issue.5, p.18420492, 2008. ,
Soybean b-Conglycinin Prevents Age-Related Hearing Impairment, PLOS ONE, vol.10, issue.9, p.137493, 2015. ,
Genistein potentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem, vol.311, issue.1-2, p.18165926, 2008. ,
Chromium III ions imitate the estradiol influence on expression of insulin pathway related genes and proteins in mouse myocytes cell line C2C12. Trace Elements and Electrolytes, vol.33, pp.28-34, 2016. ,
Activation of alpha1A-adrenoceptors by genistein at concentrations lower than that to inhibit tyrosine kinase in cultured C2C12 cells, Planta Med, vol.70, issue.7, p.15254853, 2004. ,
Inhibitory Mechanisms of Flavonoids on Insulin-Stimulated Glucose Uptake in MC3T3-G2/PA6 Adipose Cells, Biological & Pharmaceutical Bulletin, vol.31, issue.7, pp.1403-1409, 2008. ,
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes, Biochem Biophys Res Commun, vol.326, issue.2, p.15582607, 2005. ,
Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin, Arch Biochem Biophys, vol.300, issue.1, p.8424658, 1993. ,
SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes, Diabetologia, vol.58, issue.3, p.25476525, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01933287
Energy metabolism in the liver, Compr Physiol, vol.4, issue.1, p.24692138, 2014. ,
Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor, FEBS Lett, vol.501, issue.1, p.11457461, 2001. ,
Genistein enhances insulin-like growth factor signaling pathway in human breast cancer (MCF-7) cells, J Clin Endocrinol Metab, vol.89, issue.5, p.15126563, 2004. ,
Pharmacologic activation of estrogen receptor b increases mitochondrial function, energy expenditure, and brown adipose tissue, FASEB J, vol.31, issue.1, p.27733447, 2017. ,
Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high-fat-fed ovariectomized mice, Physiol Rep, vol.4, issue.17, p.11, 2016. ,
, Accepted after reviews, 2018.