Long-term reverse remodeling by cardiac resynchronization therapy with MultiPoint Pacing: A feasibility study of noninvasive hemodynamics–guided device programming - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Heart Rhythm Année : 2018

Long-term reverse remodeling by cardiac resynchronization therapy with MultiPoint Pacing: A feasibility study of noninvasive hemodynamics–guided device programming

Peter Lercher
  • Fonction : Auteur
Maurizio Lunati
  • Fonction : Auteur
Roberto Rordorf
  • Fonction : Auteur
Maurizio Landolina
  • Fonction : Auteur
Nima Badie
  • Fonction : Auteur
Fujian Qu
  • Fonction : Auteur
Cyrille Casset
  • Fonction : Auteur
Kyungmoo Ryu
  • Fonction : Auteur
Stefano Ghio
  • Fonction : Auteur
Jagmeet P. Singh
  • Fonction : Auteur

Résumé

BackgroundCardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing (MultiPoint Pacing [MPP]) improves acute hemodynamics and chronic outcomes in comparison to conventional biventricular pacing (BiV), though MPP programming questions persist.ObjectivesIn this multicenter feasibility study, we evaluated the feasibility of using noninvasive systolic blood pressure (SBP) to guide MPP programming and assessed the chronic 6-month echocardiographic CRT response.MethodsPatients implanted with MPP-enabled CRT-defibrillator devices underwent noninvasive hemodynamic assessment (finger arterial pressure) during a pacing protocol that included atrial-only pacing and various BiV and MPP configurations. Each configuration was repeated 4 times, alternating with a reference pacing configuration, to calculate the SBP difference relative to reference (ΔSBP). CRT configurations with the greatest ΔSBP were programmed. An independent core laboratory analyzed baseline and 6-month echocardiograms, with CRT response defined as a 6-month reduction in LV end-systolic volume ≥ 15%.ResultsForty-two patients (71% male; LV ejection fraction 30.3% ± 7.5%; QRS duration 161 ± 19 ms; 26% had ischemic cardiomyopathy) were enrolled in 4 European centers. Relative to atrial-only pacing, the best BiV and best MPP configurations produced significant SBP elevations of 3.1 ± 4.2 (P < .01) and 4.1 ± 4.1 mm Hg (P < .01), respectively (BiV vs MPP; P < .01). Greater SBP elevations were associated with the best MPP compared with the best BiV configurations in 29 of 37 patients completing the pacing protocol (78%). Of MPP-programmed patients completing the 6-month follow-up visit, 23 of 27 (85%) were classified as CRT responders (6-month reduction in LV end-systolic volume 37.0% ± 13.6%).ConclusionAcute noninvasive hemodynamics after CRT device implantation predominantly favored MPP over BiV programming. MPP programming guided by noninvasive hemodynamics resulted in positive LV structural remodeling.
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Dates et versions

hal-01928068 , version 1 (14-12-2018)

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Peter Lercher, Maurizio Lunati, Roberto Rordorf, Maurizio Landolina, Nima Badie, et al.. Long-term reverse remodeling by cardiac resynchronization therapy with MultiPoint Pacing: A feasibility study of noninvasive hemodynamics–guided device programming. Heart Rhythm, 2018, 15 (12), pp.1766-1774. ⟨10.1016/j.hrthm.2018.06.032⟩. ⟨hal-01928068⟩
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