Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells

Appala Venkata Ramana Murthy (1) , Vennu Narendar , Nangunoori Sampath Kumar , Pasula Aparna (1) , Anagani Kanaka Durga Bhavani , Fabien Gautier (2) , Sophie Barillé-Nion (2) , Philippe Juin (2) , Paul Mosset (3) , René Grée (3) , Nicolas Levoin (4)

1 JNU - Jawaharlal Nehru University
2 CRCINA-ÉQUIPE 8 - Stress Adaptation and Tumor Escape in Breast Cancer
3 ISCR - Institut des Sciences Chimiques de Rennes
4 Bioprojet-Biotech

Keywords: PUMA; Protein-protein interactions; Bcl-xL; BRET; Cancer; Molecular modelling

Domains: Chemical Sciences; Medicinal Chemistry; Life Sciences [q-bio]; Cancer

Appala Venkata Ramana Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, Anagani Kanaka Durga Bhavani, et al.. Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells. European Journal of Medicinal Chemistry, 2019, 162, pp.334-347. ⟨10.1016/j.ejmech.2018.10.069⟩. ⟨hal-01937242⟩