K. Strebhardt, A. Ullrich, and . Paul, Ehrlich's Magic Bullet Concept: 100 Years of Progress, Nat. Rev. Cancer, vol.8, pp.473-480, 2008.
DOI : 10.1038/nrc2394

V. P. Torchilin, Recent Advances with Liposomes as Pharmaceutical Carriers, Nat. Rev. Drug Discov, vol.4, pp.145-160, 2005.
DOI : 10.1038/nrd1632

A. S. Hoffman, Controlled" Drug Delivery Systems, J. Control. Release, vol.132, pp.153-163, 2008.

S. Liu, R. Maheshwari, and K. L. Kiick, Polymer-Based Therapeutics, Macromolecules, vol.42, pp.3-13, 2009.

Y. Malam, M. Loizidou, and A. M. Seifalian, Liposomes and Nanoparticles: Nanosized Vehicles for Drug Delivery in Cancer, Trends Pharmacol. Sci, vol.30, pp.592-599, 2009.

R. Misra, S. Acharya, and S. K. Sahoo, Cancer Nanotechnology: Application of Nanotechnology in Cancer Therapy, Drug Discov. Today, vol.15, pp.842-850, 2010.

M. L. Etheridge, S. A. Campbell, A. G. Erdman, C. L. Haynes, S. M. Wolf et al., The Big Picture on Nanomedicine: The State of Investigational and Approved Nanomedicine Products, Nanomed. Nanotechnol. Biol. Med, vol.9, pp.1-14, 2013.

S. E. Jin, H. E. Jin, and S. S. Hong, Targeted Delivery System of Nanobiomaterials in Anticancer Therapy: From Cells to Clinics, BioMed Res. Int, 2014.

J. H. Park, S. Lee, J. H. Kim, K. Park, K. Kim et al., Polymeric Nanomedicine for Cancer Therapy, Prog. Polym. Sci, vol.33, pp.113-137, 2008.

A. Kumari, S. K. Yadav, and S. C. Yadav, Biodegradable Polymeric Nanoparticles Based Drug Delivery Systems, Colloids Surf. B Biointerfaces, vol.75, pp.1-18, 2010.

B. D. Ulery, L. S. Nair, and C. T. Laurencin, Biomedical Applications of Biodegradable Polymers, J. Polym. Sci. Part B Polym. Phys, vol.49, pp.832-864, 2011.

B. S. Tucker, B. S. Sumerlin, and . Poly, N-(2-Hydroxypropyl) Methacrylamide)-Based Nanotherapeutics, Polym. Chem, vol.5, pp.1566-1572, 2014.
DOI : 10.1039/c3py01279d

K. M. El-say and H. S. El-sawy, Polymeric Nanoparticles: Promising Platform for Drug Delivery, Int. J. Pharm, vol.528, pp.675-691, 2017.

A. S. Deshmukh, P. N. Chauhan, M. N. Noolvi, K. Chaturvedi, K. Ganguly et al., Polymeric Micelles: Basic Research to Clinical Practice, Int. J. Pharm, vol.532, pp.249-268, 2017.

M. Marguet, C. Bonduelle, and S. Lecommandoux, Multicompartmentalized Polymeric Systems: Towards Biomimetic Cellular Structure and Function, Chem. Soc. Rev, vol.42, pp.512-529, 2012.
DOI : 10.1039/c2cs35312a

URL : https://hal.archives-ouvertes.fr/hal-00926540

G. Kale, T. Kijchavengkul, R. Auras, M. Rubino, S. E. Selke et al., Compostability of Bioplastic Packaging Materials: An Overview, Macromol. Biosci, vol.7, pp.255-277, 2007.

H. Seyednejad, A. H. Ghassemi, C. F. Van-nostrum, T. Vermoden, and W. E. Hennick, Functional aliphatic polyesters for biomedical and pharmaceutical applications, J. Control. Release, vol.152, pp.168-176, 2011.

A. Sauer, A. Kapelski, C. Fliedel, S. Dagorne, M. Kol et al., Structurally Well-Defined Group 4 Metal Complexes as Initiators for the Ring-Opening Polymerization of Lactide Monomers, Dalton Trans, vol.42, pp.9007-9023, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02120803

D. Chaturvedi, S. Mishra, P. Tandon, J. A. Portilla-arias, and S. Muñoz-guerra, Thermal Degradation and Theoretical Interpretation of Vibrational Spectra of Poly (?,L-Malic Acid), Polymer, vol.52, pp.3118-3126, 2011.

S. Philip, T. Keshavarz, I. Roy, and . Polyhydroxyalkanoates, Biodegradable Polymers with a Range of Applications, J. Chem. Technol. Biotechnol, vol.82, pp.233-247, 2007.

M. C. Tanzi, P. Verderio, M. G. Lampugnani, M. Resnati, E. Dejana et al., Cytotoxicity of Some Catalysts Commonly Used in the Synthesis of Copolymers for Biomedical Use, J. Mater. Sci. Mater. Med, vol.5, pp.393-396, 1994.

P. Loyer and S. Cammas-marion, Natural and Synthetic Poly (Malic Acid)-Based Derivates: A Family of Versatile Biopolymers for the Design of Drug Nanocarriers, J. Drug Target, vol.22, pp.556-575, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01063205

Z. W. Huang, V. Laurent, G. Chetouani, J. Y. Ljubimova, E. Holler et al., Cammas-Marion, S. New Functional Degradable and Bio-Compatible Nanoparticles Based on Poly (Malic Acid) Derivatives for Site-Specific Anti-Cancer Drug Delivery, Int. J. Pharm, vol.423, pp.84-92, 2012.

C. G. Jaffredo and S. M. Guillaume, Benzyl ?-Malolactonate Polymers: A Long Story with Recent Advances, Polym. Chem, vol.5, pp.4168-4194, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01077996

O. Coulembier, P. Degée, S. Cammas-marion, P. Guérin, and P. Dubois, New Amphiphilic Poly [(R,S)-?-Malic Acid-b-?-Caprolactone] Diblock Copolymers by Combining Anionic and Coordination-Insertion Ring-Opening Polymerization, Macromolecules, vol.35, pp.9896-9903, 2002.

M. Vert and R. W. Lenz, Preparation and Properties of Poly-?-Malic Acid: A Functional Polyester of Potential Biomedical Importance, Polym. Prepr, vol.20, pp.608-611, 1979.

S. Cammas, M. M. Béar, L. Moine, R. Escalup, G. Ponchel et al., Polymers of Malic Acid and 3-Alkylmalic Acid as Synthetic PHAs in the Design of Biocompatible Hydrolyzable Devices, Int. J. Biol. Macromol, vol.25, pp.273-282, 1999.

S. Cammas-marion and P. Guérin, Design of Malolactonic Acid Esters with a Large Spectrum of Specified Pendant Groups in the Engineering of Biofunctional and Hydrolyzable Polyesters, Macromol. Symp, vol.153, pp.167-186, 2000.

N. Venkatraj, M. J. Nanjan, P. Loyer, M. J. Chandrasekar, S. Cammas-marion et al., Malic Acid) Bearing Doxorubicin and N-Acetyl Galactosamine as a Site-Specific Prodrug for Targeting Hepatocellular Carcinoma, J. Biomater. Sci. Polym. Ed, vol.28, pp.1140-1157, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01579649

P. Loyer, W. Bedhouche, and Z. W. Huang, Cammas-Marion, S. Degradable and Biocompatible Nanoparticles Decorated with Cyclic RGD Peptide for Efficient Drug Delivery to Hepatoma Cells in Vitro, Int. J. Pharm, vol.454, pp.727-737, 2013.

E. Vene, K. Jarnouen, Z. W. Huang, W. Bedhouche, T. Montier et al., In Vitro Toxicity Evaluation and in Vivo Biodistribution of Polymeric Micelles Derived from Poly (Ethylene Glycol)-b-Poly(Benzyl Malate, Copolymer. Pharm. Nanotechnol, vol.4, pp.24-37, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01313741

S. Cammas, I. Renard, V. Langlois, and P. Guerin, Poly (?-Malic Acid): Obtaining High Molecular Weights by Improvement of the Synthesis Route, Polymer, vol.37, pp.4215-4220, 1996.

. Tetraethylammonium, , 2018.

L. Casas-godoy, S. Duquesne, F. Bordes, G. Sandoval, and A. Marty, Lipases: An Overview, Lipases and Phospholipases, pp.3-30, 2012.
DOI : 10.1007/978-1-4939-8672-9_1

A. Rauwerdink and R. J. Kazlauskas, How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: The Serine-Histidine-Aspartate Catalytic Triad of ?/?-Hydrolase Fold Enzymes, ACS Catal, vol.5, pp.6153-6176, 2015.

S. Shoda, H. Uyama, J. Kadokawa, S. Kimura, and S. Kobayashi, Enzymes as Green Catalysts for Precision Macromolecular Synthesis, Chem. Rev, vol.116, pp.2307-2413, 2016.

R. T. Macdonald, S. K. Pulapura, Y. Y. Svirkin, R. A. Gross, D. L. Kaplan et al., Enzyme-Catalyzed Epsilon.-Caprolactone Ring-Opening Polymerization, Macromolecules, vol.28, pp.73-78, 1995.

L. A. Henderson, Y. Y. Svirkin, R. A. Gross, D. L. Kaplan, and G. Swift, Enzyme-Catalyzed Polymerizations of ?-Caprolactone, Effects of Initiator on Product Structure, Propagation Kinetics, and Mechanism. Macromolecules, vol.29, pp.7759-7766, 1996.

P. M. Johnson, S. Kundu, and K. L. Beers, Modeling Enzymatic Kinetic Pathways for Ring-Opening Lactone Polymerization, Biomacromolecules, vol.12, pp.3337-3343, 2011.

S. Kobayashi, Enzymatic Polymerization: A New Method of Polymer Synthesis, J. Polym. Sci. Part A Polym. Chem, vol.37, pp.3041-3056, 1999.

S. Kobayashi and . Green, Polymer Chemistry: New Methods of Polymer Synthesis Using Renewable Starting Materials, Struct. Chem, vol.28, pp.461-474, 2016.

A. C. Albertsson and R. K. Srivastava, Recent Developments in Enzyme-Catalyzed Ring-Opening Polymerization, Adv. Drug Deliv. Rev, vol.60, pp.1077-1093, 2008.

H. Casajus, S. Tranchimand, D. Wolbert, and C. Nugier-chauvin, Cammas-Marion, S. Optimization of Lipase-Catalyzed Polymerization of Benzyl Malolactonate through a Design of Experiment Approach, J. Appl. Polym. Sci, vol.134, 2017.

O. Thioune, H. Fessi, J. P. Devissaguet, and F. Puisieux, Preparation of Pseudolatex by Nanoprecipitation: Influence of the Solvent Nature on Intrinsic Viscosity and Interaction Constant, Int. J. Pharm, vol.146, pp.233-238, 1997.

C. J. Martínez-rivas, M. Tarhini, W. Badri, K. Miladi, H. Greige-gerges et al., Nanoprecipitation Process: From Encapsulation to Drug Delivery, Int. J. Pharm, vol.532, pp.66-81, 2017.

V. Laurent, D. Glaise, T. Nübel, D. Gilot, A. Corlu et al., Highly Efficient SiRNA and Gene Transfer into Hepatocyte-Like HepaRG Cells and Primary Human Hepatocytes: New Means for Drug Metabolism and Toxicity Studies, Cytochrome P450 Protocols, vol.987, pp.295-314, 2013.
DOI : 10.1007/978-1-62703-321-3_25

URL : https://hal.archives-ouvertes.fr/hal-00865763

E. Vène, G. Barouti, K. Jarnouen, T. Gicquel, C. Rauch et al., Opsonisation of nanoparticles prepared from poly (?-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells, Int. J. Pharm, vol.13, pp.438-452, 2016.

S. Matsumura, Enzymatic Synthesis of Polyesters via Ring-Opening Polymerization. In Enzyme-Catalyzed Synthesis of Polymers

S. Kobayashi, H. Ritter, and D. Kaplan, , vol.194, pp.95-132, 2005.

H. Uyama, K. Takeya, and S. Kobayashi, Synthesis of Polyesters by Enzymatic Ring-Opening Copolymerization Using Lipase Catalyst, Proc. Jpn. Acad. Ser. B, vol.69, pp.203-207, 1993.

H. Kikuchi, H. Uyama, and S. Kobayashi, Lipase-Catalyzed Ring-Opening Polymerization of Substituted Lactones, Polym. J, vol.34, pp.835-840, 2002.

S. Matsumura, H. Beppu, K. Nakamura, S. Osanai, and K. Toshima, Preparation of Poly (?-Malic Acid) by Enzymatic Ring-Opening Polymerization of Benzyl ?-Malolactonate, Chem. Lett, vol.25, pp.795-796, 1996.

A. A. Panova, S. Taktak, S. Randriamahefa, S. Cammas-marion, P. Guerin et al., Polymerization of Propyl Malolactonate in the Presence of Candida Rugosa Lipase, Biomacromolecules, vol.4, pp.19-27, 2003.

P. Guerin, J. Francillette, C. Braud, and M. Vert, Benzyl esters of optically active malic acid stereocopolymers as obtained by ring-opening polymerization of (R)-(+) and (S)-(-)-benzyl malolactonates, Macromol. Symp, vol.6, pp.305-314, 1986.

V. Cerec, D. Glaise, D. Garnier, S. Morosan, B. Turlin et al., Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.45, pp.957-967, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00690471

C. Aninat, A. Piton, D. Glaise, T. Le-charpentier, S. Langouet et al., Expression of cytochrome P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells, Drug Metab. Dispos, vol.34, pp.75-83, 2006.

N. Quesnot, S. Bucher, C. Gade, M. Vlach, E. Vène et al., Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes, Arch. Toxicol, vol.92, pp.3077-3091, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01863847

R. Jossé, C. Aninat, D. Glaise, J. Dumont, V. Fessard et al., Long-term functional stability of HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies, Drug Metab. Dispos, vol.36, pp.1111-1118, 2008.

J. Dumont, R. Jossé, C. Lambert, S. Anthérieu, V. Laurent et al., Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines, Toxicol. Appl. Pharmacol, vol.249, pp.91-100, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00742145

N. Quesnot, K. Rondel, S. Martinais, M. Audebert, D. Glaise et al., Evaluation of genotoxicity using automated detection of gammaH2AX in metabolically competent HepaRG cells, Mutagenesis, vol.31, pp.43-50, 2016.

G. Barouti, K. Jarnouen, S. Cammas-marion, P. Loyer, and S. Guillaume, Polyhydroxylakanoate-based diblock copolymers: Potential biocompatible nanovectors, Polym. Chem, vol.6, pp.5414-5429, 2015.
DOI : 10.1039/c5py00831j