, 1 mmol) and N-bromosuccinimide (0.356 g, 2 mmol) were dissolved in DMF (5 mL) under an argon atmosphere. The reaction mixture was stirred at 50 °C for 3 h. Then, the solvent was evaporated and the product was purified by silica gel column chromatography

, mmol), 2-isopropyl4-methylylthiazole (0.141 g, 1 mmol), KOAc (0.098 g, 1 mmol) and PdCl(C3H5)(dppb) (6.1 mg, 0.01 mmol) were dissolved in DMA (2 mL) under an argon atmosphere. The reaction mixture was stirred at 150 °C for 16 h. Then, the solvent was evaporated and the product was purified by silica gel column chromatography, Hz, 1H), 7.76-7.58 (m, 4H), 3.44 (t, J = 7.6 Hz, 2H), 1.98-1.87 (m, 1H), 1.74-1.64 (m, 2H), 1.16 (d, J = 7.6 Hz, 6H). 13 C NMR (100 MHz, CDCl3): ? 137, vol.6

, 16 (s, 3H), 1.64-1.54 (m, 3H), 1.53 (d, J = 7.6 Hz, 6H), 0.93 (d, J = 7.6 Hz, 6H), Hz, 1H), 7.75-7.68 (m, 2H), 7.63 (t, J = 7.8 Hz, 1H), 7.58-7.50 (m, 2H), 3.50-3.38 (m, 1H), 3.11-2.90 (m, 2H), vol.2

, KOAc (0.098 g, 1 mmol) and PdCl(C3H5)(dppb) (6.1 mg, 0.01 mmol) were dissolved in DMA (2 mL) under an argon atmosphere. The reaction mixture was stirred at 150 °C for 16 h. Then, the solvent was evaporated and the product was purified by silica gel column chromatography, Product 36 was obtained in 80% (0.132 g) yield as a white solid: mp 104-106 °C. 1 H NMR (400 MHz

, Hz, 1H), 7.07 (d, J = 2.8 Hz, 1H), 3.07-2.94 (m, 2H), 1.72-1.54 (m, 3H), 0.91 (d, J = 7.6 Hz, 6H). 13 C NMR (100 MHz, CDCl3): ? 140, vol.6

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