P. M. Elliot, A. Anastas, and M. A. Borger, ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), Eur Heart J, vol.35, pp.2733-2779, 2014.

A. J. Marian and E. Braunwald, Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy, Circ Res, vol.121, issue.7, 2017.

R. H. Chan, B. J. Maron, and I. Olivotto, Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy, Circulation, vol.130, pp.484-495, 2014.

R. Hinojar, C. Fernández-golfín, and A. González-gómez, Prognostic implications of global myocardial mechanics in hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking. Relations to left ventricular hypertrophy and fibrosis, Int J Cardiol, vol.249, pp.467-472, 2017.

P. Reant, M. Mirabel, and G. Lloyd, Global longitudinal strain is associated with heart failure outcomes in hypertrophic cardiomyopathy, Heart Br Card Soc, vol.102, pp.741-747, 2016.

E. Galli, C. Leclercq, and M. Fournet, Value of Myocardial Work Estimation in the Prediction of Response to Cardiac Resynchronization Therapy, J Am Soc Echocardiogr, vol.31, pp.220-230, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01718026

E. Galli, C. Leclercq, and A. Hubert, Role of myocardial constructive work in the identification of responders to CRT, Eur Heart J Cardiovasc Imaging, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01812216

K. Russell, M. Eriksen, and L. Aaberge, Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions, Am J Physiol Heart Circ Physiol, vol.305, pp.996-1003, 2013.

R. M. Lang, L. P. Badano, and V. Mor-avi, Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging, J Am Soc Echocardiogr, vol.28, pp.1-39, 2015.

S. F. Nagueh, O. A. Smiseth, and C. P. Appleton, Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging, Eur Heart J Cardiovasc Imaging, vol.17, pp.1321-1360, 2016.

J. Voigt, G. Pedrizzetti, and P. Lysyansky, Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging, J Am Soc Echocardiogr, vol.28, pp.183-193, 2015.

F. Schnell, D. Matelot, and M. Daudin, Mechanical dispersion by Strain Echocardiography: A Novel Tool to Diagnose Hypertrophic Cardiomyopathy in Athletes, J Am Soc Echocardiogr, vol.30, pp.251-261, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01502238

T. F. Haland, V. M. Almaas, and N. E. Hasselberg, Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy, Eur Heart J -Cardiovasc Imaging, vol.17, pp.613-621, 2016.

K. Russell, M. Eriksen, and L. Aaberge, A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work, Eur Heart J, vol.33, pp.724-733, 2012.

M. Guazzi, V. Adams, and V. Conraads, EACPR/AHA Scientific Statement. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations, Circulation, vol.126, pp.2261-2274, 2012.

P. E. Bravo, A. Pinheiro, and T. Higuchi, PET/CT assessment of symptomatic individuals with obstructive and nonobstructive hypertrophic cardiomyopathy, J Nucl Med, vol.53, pp.407-414, 2012.

I. Olivotto, F. Girolami, and R. Sciagrà, Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations, J Am Coll Cardiol, vol.58, pp.839-848, 2011.

T. Delhaas, T. Arts, and F. W. Prinzen, Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart, J Physiol, vol.477, pp.481-496, 1994.

E. Kong, S. Lee, and I. Cho, Myocardial Fibrosis in Hypertrophic Cardiomyopathy Demonstrated by Integrated Cardiac F-18 FDG PET/MR, Nucl Med Mol Imaging, vol.47, pp.196-200, 2013.

K. M. Harris, P. Spirito, and M. S. Maron, Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy, Circulation, vol.114, pp.216-225, 2006.

M. S. Maron, E. J. Rowin, and I. Olivotto, Contemporary Natural History and Management of Nonobstructive Hypertrophic Cardiomyopathy, J Am Coll Cardiol, vol.67, pp.1399-1409, 2016.

S. S. Lele, H. L. Thomson, and H. Seo, Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume limitation, heart rate, and diastolic filling characteristics, Circulation, vol.92, pp.2886-2894, 1995.

S. Sharma, P. Elliott, and G. Whyte, Utility of cardiopulmonary exercise in the assessment of clinical determinants of functional capacity in hypertrophic cardiomyopathy, Am J Cardiol, vol.86, pp.162-168, 2000.

S. Saberi, M. Wheeler, and J. Bragg-gresham, Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial, JAMA, vol.317, pp.1349-1357, 2017.

G. Aquaro, V. Positano, and A. Pingitore, Quantitative analysis of late gadolinium enhancement in hypertrophic cardiomyopathy, J Cardiovasc Magn Reson, vol.12, p.21, 2010.

A. H. Ellims, L. M. Iles, and L. Ling, Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction, J Cardiovasc Magn Reson, vol.14, p.76, 2012.

, For each segment, myocardial work was calculated from left ventricular pressure (upper panel) and

, The myocardial work curve and the method of calculation of myocardial constructive work (CW segm ) and wasted work (WW segm ) for a LV segment are depicted in the lower panel. Constructive and wasted work are marked respectively as grey and red segments

, AVC, aortic valve closure

, AVO, aortic valve opening

, CW, constructive work; IVC, isovolumic contraction

, IVR, isovolumic relaxation

, E, left ventricular ejection

, MVC, mitral valve closure

, MVO, mitral valve opening