Macrophage functions in wound healing

Malgorzata Kloc; Rafik M Ghobrial; Jarek Wosik; Aneta Lewicka; Sławomir Lewicki; Jacek Z Kubiak

doi:10.1002/term.2772

Journal articles

Macrophage functions in wound healing

Malgorzata Kloc ^{1, 2, *} Rafik M Ghobrial ¹ Jarek Wosik ³ Aneta Lewicka ⁴ Sławomir Lewicki ⁴ Jacek Z Kubiak ^{4, 5}

* Corresponding author

1 The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.

2 The University of Texas M.D. Anderson Cancer Center [Houston]

3 University of Houston

4 WIHE - Military Institute of Hygiene and Epidemiology

5 IGDR - Institut de Génétique et Développement de Rennes

Abstract : Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Keywords : macrophages CX3CR1 ROCK kinase RhoAactin wound healing

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Genetics

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01975698
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Submitted on : Friday, January 25, 2019 - 12:00:41 PM
Last modification on : Thursday, January 14, 2021 - 11:15:46 AM
Long-term archiving on: : Friday, April 26, 2019 - 12:33:32 PM

Macrophage functions in wound healing

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Macrophage functions in wound healing

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