Macrophage functions in wound healing

Malgorzata Kloc (1, 2) , Rafik M Ghobrial (1) , Jarek Wosik (3) , Aneta Lewicka (4) , Sławomir Lewicki (4) , Jacek Z Kubiak (4, 5)

1 Methodist Hospital Research Institute
2 The University of Texas M.D. Anderson Cancer Center [Houston]
3 University of Houston
4 WIHE - Military Institute of Hygiene and Epidemiology
5 IGDR - Institut de Génétique et Développement de Rennes

Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Keywords: wound healing; macrophages; CX3CR1; ROCK kinase; RhoAactin

Domains: Life Sciences [q-bio]; Genetics

Malgorzata Kloc, Rafik M Ghobrial, Jarek Wosik, Aneta Lewicka, Sławomir Lewicki, et al.. Macrophage functions in wound healing. Journal of Tissue Engineering and Regenerative Medicine, 2019, 13 (1), pp.99-109. ⟨10.1002/term.2772⟩. ⟨hal-01975698⟩