Self-other recognition impairments in individuals with schizophrenia a new experimental paradigm using a double mirror

Gaelle Keromnes (1, 2) , Tom Motillon (1, 2) , Nathalie . Coulon (3, 4, 5) , Alain Berthoz (6) , Foucaud Du Boisgueheneuc (7) , Moritz Wehrmann (6, 8) , Brice Martin (9) , Bérangère Thirioux (6) , Olivier Bonnot (10) , Romain Ridereau (1, 2) , Eric Bellissant (2, 11) , Dominique Drapier (2, 1) , David Levoyer (1, 2) , Nemat Jaafari (12, 13) , Sylvie Tordjman (3, 11, 1)

1 Centre Hospitalier Guillaume Régnier [Rennes]
2 CHU Pontchaillou [Rennes]
3 LPP - UMR 8242 - Laboratoire Psychologie de la Perception
4 CHU - BREST - Hopital de Bohars - CHRU Brest
5 UPD5 - Université Paris Descartes - Paris 5
6 LPPA - Laboratoire de Physiologie de la Perception et de l'Action
7 CHU Poitiers - Centre hospitalier universitaire de Poitiers
8 Bauhaus-Universität Weimar
9 CNC - Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229
10 Psychiatrie de l'enfant et de l'adolescent [CHU Nantes]
11 CIC - Centre d'Investigation Clinique [Rennes]
12 CIC - Poitiers
13 LNEC - Laboratoire de neurosciences expérimentales et cliniques

Clinical observations suggest early self-consciousness disturbances in schizophrenia. A double mirror combining the images of two individuals sitting on each side of the mirror was used to study self-other differentiation in 12 individuals with early onset schizophrenia (EOS) and 15 individuals with adult onset schizophrenia (AOS) compared to 27 typically developing controls (TDC) matched on age and sex. The effects of intermodal sensory perception (visual-tactile and visual-kinesthetic) on self-other recognition were also studied. The results showed that EOS and AOS individuals, independently of age and schizophrenia severity, were centered on their own image compared to TDC, with both significant earlier self-recognition and delayed other-recognition during the visual recognition task. In addition, there was no significant effect of intermodal sensory stimulation on self-other recognition in EOS and AOS patients, whereas self-centered functioning was significantly increased by visual-tactile stimulation and decreased by visual-kinesthetic stimulation in TDC. The findings suggest that self-other recognition impairments might be a possible endophenotypic trait of schizophrenia.

Domains: Life Sciences [q-bio]; Human health and pathology; Psychiatrics and mental health

Gaelle Keromnes, Tom Motillon, Nathalie . Coulon, Alain Berthoz, Foucaud Du Boisgueheneuc, et al.. Self-other recognition impairments in individuals with schizophrenia a new experimental paradigm using a double mirror. npj Schizophrenia, 2018, 4 (1), pp.24. ⟨10.1038/s41537-018-0065-5⟩. ⟨hal-01975937⟩