Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

M Yefimova (1) , N Bourmeyster (2) , F Becq (2) , A Burel (3) , M-T Lavault (3) , G Jouve (1) , S Veau (1) , C Pimentel (1) , Bernard Jégou (4, 5) , Célia Ravel (4)

1 CHU Pontchaillou [Rennes]
2 STIM - Signalisation et Transports Ioniques Membranaires
3 MRic - Centre de Microscopie de Rennes
4 Irset - Institut de recherche en santé, environnement et travail
5 EHESP - École des Hautes Études en Santé Publique [EHESP]

CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management.

Keywords: Spermatozoa; Mutation; Sertoli cell; Testis; Assisted reproductive technology; Epididymis; Cystic fibrosis

Domains: Life Sciences [q-bio]

M Yefimova, N Bourmeyster, F Becq, A Burel, M-T Lavault, et al.. Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility. Morphologie, 2019, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩. ⟨hal-01976465⟩