3MRic - Centre de Microscopie de Rennes (Biosit - Université de Rennes 1 - Campus de Villejean - Bât. 8 - 2 avenue du Professeur Léon Bernard - 35043 Rennes Cedex - France)
Abstract : CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01976465
Contributor : Laurent Jonchère
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Submitted on : Thursday, January 10, 2019 - 9:49:12 AM
Last modification on : Friday, November 29, 2019 - 1:46:07 AM
M Yefimova, N Bourmeyster, F Becq, A Burel, M-T Lavault, et al.. Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility. Morphologie, 2018, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩. ⟨hal-01976465⟩
