Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

M Yefimova (1) , Nicolas Bourmeyster (2) , F Becq (2) , A Burel (3) , M-T Lavault (3) , G Jouve (1) , S Veau (1) , C Pimentel (1) , Bernard Jégou (4, 5) , Célia Ravel (4)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 STIM [Poitiers] - Signalisation et Transports Ioniques Membranaires
3 MRic - Centre de Microscopie de Rennes
4 Irset - Institut de recherche en santé, environnement et travail
5 EHESP - École des Hautes Études en Santé Publique [EHESP]

CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management.

Mots clés: Spermatozoa; Mutation; Sertoli cell; Testis; Assisted reproductive technology; Epididymis; Cystic fibrosis

Domaines: Sciences du Vivant [q-bio]

M Yefimova, Nicolas Bourmeyster, F Becq, A Burel, M-T Lavault, et al.. Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility. Morphologie, 2019, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩. ⟨hal-01976465⟩