Skip to Main content Skip to Navigation
Journal articles

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

Jodi L Pawluski 1, 2 Ursula Brain 3 Geoffrey L Hammond 3 Tim F Oberlander 3
1 Irset - Institut de recherche en santé, environnement et travail
2 EHESP - École des Hautes Études en Santé Publique [EHESP]
3 UBC - University of British Columbia
Abstract : The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.
Keywords : Gestation Anxiety Depression Neuroplasticity Motherhood Antidepressants
Document type :
Journal articles
Complete list of metadatas

Cited literature [24 references]  Display  Hide  Download
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01976469
Contributor : Laurent Jonchère <>
Submitted on : Monday, January 14, 2019 - 3:08:18 PM
Last modification on : Wednesday, January 15, 2020 - 1:23:32 PM

File

Vignette du document
Pawluski_Selective Serotonin R...
Files produced by the author(s)

Identifiers

Collections

UNIV-RENNES1 | UNIV-RENNES | UR1-UFR-SVE | UNIV-ANGERS | BIOSIT | IRSET

Citation

Jodi L Pawluski, Ursula Brain, Geoffrey L Hammond, Tim F Oberlander. Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression. Archives of Women's Mental Health, Springer Verlag, 2019, 22 (3), pp.431-435. ⟨10.1007/s00737-018-0931-1⟩. ⟨hal-01976469⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

120

Files downloads

207