Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

Jodi L Pawluski 1, 2 Ursula Brain 3 Geoffrey L Hammond 3 Tim F Oberlander 3
1 Irset - Institut de recherche, santé, environnement et travail
2 EHESP - École des Hautes Études en Santé Publique [EHESP]
3 UBC - University of British Columbia
Abstract : The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.
Keywords : Antidepressants Motherhood Neuroplasticity Depression Anxiety Gestation
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Jodi L Pawluski, Ursula Brain, Geoffrey L Hammond, Tim F Oberlander. Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression. Archives of Women's Mental Health, Springer Verlag, 2018, 22 (3), pp.431-435. ⟨10.1007/s00737-018-0931-1⟩. ⟨hal-01976469⟩

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