Manganese catalyzed α-methylation of ketones with methanol as a C1 source

Abstract : The direct α-methylation of ketones with methanol under hydrogen borrowing conditions using a well-defined manganese PN3P complex as a pre-catalyst was, for the first time, achieved. The reactions typically proceed at 120 °C for 20 h with 3 mol% pre-catalyst loading and in the presence of NaOtBu (50 mol%) as base. The scope of the reaction was extended to the α-methylation of esters.
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Antoine Bruneau-Voisine, Lenka Pallova, Stéphanie Bastin, Vincent César, Jean-Baptiste Sortais. Manganese catalyzed α-methylation of ketones with methanol as a C1 source. Chemical Communications, Royal Society of Chemistry, 2019, 55 (3), pp.314-317. ⟨10.1039/c8cc08064j⟩. ⟨hal-01976517⟩

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