Work-Related Stressors and Increased Risk of Benzodiazepine Long-Term Use Findings From the CONSTANCES Population-Based Cohort

Abstract : Objectives. To examine whether stressful job exposure to the public could be associated with having long-term benzodiazepine use. Methods. From the participants included between 2012 and 2016 in the French population-based CONSTANCES cohort, 13 934 men and 19 261 women declared a daily job exposure to the public and rated the frequency of stressful exposure. We examined benzodiazepine long-term use by using drug reimbursement administrative registries. Logistic regressions provided odds ratios (ORs) of benzodiazepine long-term use, with stratification for gender and adjustment for age, education, and area deprivation index. Occupational grade, job strain, depression, self-rated health, and alcohol use disorder were additional stratification variables. Results. Benzodiazepine long-term use was positively associated with stressful exposure to the public ("often or always" vs "rarely or never") in men (OR = 2.2; 95% confidence interval [CI] = 1.8, 2.8) and women (OR = 1.6; 95% CI = 1.4, 1.9), with dose-dependent relationships (P trends <.001). Adjustments and analyses in subgroups without other individual or environmental vulnerability factors led to similar results. Conclusions. Stressful job exposure to the public increases the risk of benzodiazepine long-term use. Prevention programs aiming at reducing the burden of benzodiazepine longterm use would benefit in targeting this specific population.
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Submitted on : Friday, January 11, 2019 - 3:19:53 PM
Last modification on : Thursday, April 11, 2019 - 4:02:54 PM

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Guillaume Airagnes, Cedric Lemogne, Romain Olekhnovitch, Yves Roquelaure, Nicolas Hoertel, et al.. Work-Related Stressors and Increased Risk of Benzodiazepine Long-Term Use Findings From the CONSTANCES Population-Based Cohort. American Journal of Public Health, American Public Health Association, 2019, 109 (1), pp.119-125. ⟨10.2105/AJPH.2018.304734⟩. ⟨hal-01978480⟩

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