An Update on the Effects of Glyceollins on Human Health Possible Anticancer Effects and Underlying Mechanisms

Thu Ha Pham (1, 2) , Sylvain Lecomte (1, 2) , Theo Efstathiou (3) , François Ferriere (2, 1) , Farzad Pakdel (1, 2)

1 EHESP - École des Hautes Études en Santé Publique [EHESP]
2 Irset - Institut de recherche en santé, environnement et travail
3 Nutrinov

Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications.

Keywords: signaling pathways; estrogen receptor; dietary compounds; human health; phytochemicals; glyceollins; breast cancer

Domains: Life Sciences [q-bio]; Food and Nutrition; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Ecology, environment; Health

Thu Ha Pham, Sylvain Lecomte, Theo Efstathiou, François Ferriere, Farzad Pakdel. An Update on the Effects of Glyceollins on Human Health Possible Anticancer Effects and Underlying Mechanisms. Nutrients, 2019, 11 (1), pp.79. ⟨10.3390/nu11010079⟩. ⟨hal-01978725⟩