Convenient Access to C10- and C11-(di)arylated dibenzo[ b , f ]azepines via Palladium-catalyzed C−H Bonds Cleavages
Résumé
Conditions allowing the C10‐ and C11‐arylations of dibenzo[b,f]azepines via successive palladium‐catalyzed reactions are reported. Using aryl bromides as the aryl source, the C10‐arylation of dibenzo[b,f]azepines is very selective. Then, using benzenesulfonyl chlorides as the aryl source, the second arylation at C11‐position is achieved affording non‐symmetrical C10,C11‐diarylated dibenzo[b,f]azepines. Both reactions tolerate a variety of substituents on the aryl source.
Domaines
Chimie
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Li et al_Convenient access to C10- and C11-(di)arylated dibenzo[b,f]azepines via.pdf (576.06 Ko)
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