Aurora A Protein Kinase To the Centrosome and Beyond

Laura Magnaghi-Jaulin (1) , Grégory Eot-Houllier (1) , Emmanuel Gallaud (1) , Régis Giet (1)

1 IGDR - Institut de Génétique et Développement de Rennes

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the cellular cytoskeleton. Isolated more than two decades ago from , Aurora A is a widespread protein kinase that plays key roles during cell division. Numerous studies have described the localisation of Aurora A at centrosomes, the mitotic spindle, and, more recently, at mitotic centromeres. In this review, we will summarise the cytoskeletal rearrangements regulated by Aurora A during cell division. We will also discuss the recent discoveries showing that Aurora A also controls not only the dynamics of the cortical proteins but also regulates the centromeric proteins, revealing new roles for this kinase during cell division.

Mots clés: centrosome; cohesion; kinetochore; Aurora A protein kinase; mitotic spindle; transcription; centromere; polarity

Domaines: Biochimie, Biologie Moléculaire

Laura Magnaghi-Jaulin, Grégory Eot-Houllier, Emmanuel Gallaud, Régis Giet. Aurora A Protein Kinase To the Centrosome and Beyond. Biomolecules, 2019, 9 (1), pp.E28. ⟨10.3390/biom9010028⟩. ⟨hal-01993661⟩