Echocardiographic reference ranges for normal non-invasive myocardial work indices results from the EACVI NORRE study

Roberta Manganaro (1) , Stella Marchetta (1) , Raluca Dulgheru (1) , Federica Ilardi (1) , Tadafumi Sugimoto (1) , Sébastien Robinet (1) , Sara Cimino (1) , Yun Yun Go (1) , Anne Bernard (2) , George Kacharava , George D Athanassopoulos , Daniele Barone , Monica Baroni , Nuno Cardim , Andreas Hagendorff (3) , Krasimira Hristova , Teresa López-Fernández , Gonzalo de La Morena , Bogdan A Popescu , Martin Penicka , Tolga Ozyigit , Jose David Rodrigo Carbonero , Nico van de Veire , Ralph Stephan von Bardeleben , Dragos Vinereanu , Jose Luis Zamorano (4) , Monica Rosca , Andreea Calin , Marie Moonen (1) , Julien Magne (5) , Bernard Cosyns (6) , Elena Galli (7, 8) , Erwan Donal (7, 8) , Scipione Carerj (9) , Concetta Zito (9) , Ciro Santoro , Maurizio Galderisi , Luigi P Badano , Roberto M Lang , Cecile Oury (1) , Patrizio Lancellotti (1)

1 CHU-Liège - Centre Hospitalier Universitaire de Liège
2 CHU Trousseau [Tours]
3 Universität Leipzig [Leipzig]
4 UAH - Universidad de Alcalá - University of Alcalá
5 NET - Neuroépidémiologie Tropicale
6 In vivo Cellular and Molecular Imaging Laboratory
7 CIC - Centre d'Investigation Clinique [Rennes]
8 CIC-IT Rennes
9 University of Messina

Aims - To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results - A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion - The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

Keywords: myocardial work; reference values; 2D echocardiography; adult echocardiography

Domains: Life Sciences [q-bio]; Bioengineering; Engineering Sciences [physics]; Signal and Image processing

Roberta Manganaro, Stella Marchetta, Raluca Dulgheru, Federica Ilardi, Tadafumi Sugimoto, et al.. Echocardiographic reference ranges for normal non-invasive myocardial work indices results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging, 2019, 20 (5), pp.582-590. ⟨10.1093/ehjci/jey188⟩. ⟨hal-01998532⟩