Regulat-INGs in tumors and diseases: Focus on ncRNAs

Abstract : ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvement of non-coding RNAs (ncRNAs) and in particular microRNAs (miRNAs) in post-transcriptional gene regulation is well established. miRNAs are short sequences (18-25 nucleotides) that can bind to the 3 'UTR sequence of the targeted messenger RNA (mRNA), leading to its degradation or translational repression. Interactions between the ING family and miRNAs have been described in some cancers but also in other diseases. The involvement of miRNAs in ING family regulation opens up new fields of investigation, particularly for targeted therapies. In this review, we will summarize the regulatory mechanisms at the RNA and protein level of the ING family and focus on the interactions with ncRNAs.
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Marjorie Gournay, Mathieu Paineau, Jérôme Archambeau, Remy Pedeux. Regulat-INGs in tumors and diseases: Focus on ncRNAs. Cancer Letters, Elsevier, 2019, 447, pp.66-74. ⟨10.1016/j.canlet.2019.01.006⟩. ⟨hal-02015576⟩

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