, Brown solid, yield = 85%, 93.0 mg, Mp > 250 o C dec. 1 H NMR (400 MHz, acetone-d 6 ): ? = 9.10 (br, 1H), 7.96-7.90 (m, 4H), vol.7
, 2-(6-Fluoro-2-hydroxyphenyl)isoindoline-1,3-dione (2l). Yellow solid, Hz, 1H), 7.66 (dd, J = 8.8, 2.4 Hz, 1H), 6.92 (d, J = 8.8 Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, p.400
, ?? = 9.31 (br, 1H), 8.01-7.94 (m, 4H), vol.7
, Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6): ? = 167.2, 160.6 (d, JC-F = 246.5 Hz), vol.156, p.376
HRMS (ESI) calcd. for [M+Na] + C14H8NO3FNa 280.0380, found 280.0383 (1 ppm). 2-(2-Hydroxy-6-methylphenyl)isoindoline-1,3-dione (2m) ,
, Colorless solid, yield = 28%, 21.1 mg, pp.145-148
22 (dd, J = 8.0, 8.0 Hz, 1H), 6.88 (dd, J = 8.0, 8.0 Hz, 2H), 2.14 (s, 3H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6): ? = 167, acetone-d6): ? = 8.75 (br, 1H), 7.97-7.91 (m, 4H), vol.7, p.400 ,
, acetone-d6): ? = 8.77 (br, 1H), 7.74-7.72 (m, 2H), 7.65-7.63 (m, 1H), 7.35-7.29 (m, 2H), vol.7, p.7
, -hydroxyphenyl)isoindoline-1,3-dione (2o)
, acetone-d6): ? = 8.82 (br, 1H), 7.95
, Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6): ? = 166.8 (d, JC-F = 3.1 Hz), vol.164
ppm). 4-Chloro-2-(2-hydroxyphenyl)isoindoline-1,3-dione (2p), Hz), 117.6 ppm. 19 F{ 1 H} NMR (376 MHz, acetone-d6): ? = -115.7 ppm. HRMS (ESI), vol.138, p.400 ,
, ?? = 8.82 (br, 1H), 7.91-7.84 (m, 3H)
-Hydroxyphenyl)-4-nitroisoindoline-1,3-dione (2q). Colorless solid, p.400 ,
, ?? = 8.87 (br, 1H), 8.30-8.25 (m, 2H), vol.8
, -Hydroxyphenyl)-5-methylisoindoline-1,3-dione (2r), Hz, 1H), 6.99 (ddd, J = 7.6, 7.6, 1.2 Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6): ? = 165, vol.9, p.400
, acetone-d6): ? = 8.71 (br, 1H), 7.81 (d, J = 7.6 Hz, 1H), 7.75 (s, 1H), 7.71 (d, J = 7.6 Hz, 1H), vol.7, pp.35-42
, -hydroxyphenyl)isoindoline-1,3-dione (2s)
, Colorless solid, yield = 87%, 77.0 mg, pp.116-119
, acetone-d6): ? = 7.96-7.95 (m, 2H), 7.86 (d, J = 8.4 Hz, 1H), 7.36-7.29 (m, 2H)
,
, -hydroxyphenyl)isoindoline-1,3-dione (2t), p.400
, Hz, 1H), 7.71-7.63 (m, 2H), 7.36-7.30 (m, 2H), 7.07 (dd, J = 8.0, 1.2 Hz, 1H), 6.98 (ddd, J = 7.6, 7.6, 1.2 Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, acetoned6):?? = 167.2 (d, JC-F = 252.5 Hz), 166.9, 166.6 (d, JC-F = 2.9 Hz), 154.8, 136.3 (d, JC-F = 9.5 Hz), 131.3 (d, JC-F = 17.7 Hz), 129.4 (d, JC-F = 2.8 Hz), 126.8 (d, JC-F = 9
, 7.00 (ddd, J = 8.0, 8.0, 1.2 Hz, 1H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6, Hz, 1H), 8.23 (d, J = 8.0 Hz, 1H), 7.39-7.33 (m, 2H), 7.09 (dd, J = 8.0, 1.2 Hz, 1H), vol.104, p.50
, 25 (ddd, J = 8.0, 8.0, 1.6 Hz, 1H), 7.09 (dd, J = 8.0, 1.6 Hz, 1H), 6.99 (d, J = 8.0 Hz, 1H), 6.91 (dd, Colorless solid, yield = 91%, 66.9 mg. Mp: 232-235 o C. 1 H NMR (400 MHz, acetone-d6): ? = 8.62 (br, 1H), vol.7
, The spectral data match those previously reported, -Hydroxyphenyl)pyrrolidine-2,5-dione (2w). Yellow solid, yield = 89%, 33.9 mg. 1 H NMR (400 MHz, acetone-d6): ? = 8.47 (br, 1H), 7.28-7.24 (m, 1H), vol.109, p.55
, 00 (dd, J = 8.0, 1.2 Hz, 1H), 6.92 (ddd, J = 7.6, 7.6, 1.2 Hz, 1H), 6.62 (q, J = 2.0 Hz, 1H), 2.11 (d, J = 2.0 Hz, 3H) ppm. 13 C{ 1 H} NMR (100 MHz, acetone-d6): ? = 171, Colorless solid, yield = 89%, 54.2 mg. 1 H NMR (400 MHz, acetone-d6): ? = 8.61 (br, 1H), 7.28 (ddd, J = 8.0, 8.0, 2.0 Hz, 1H), 7.15 (dd, J = 8.0, 2.0 Hz, 1H), vol.7, p.400
, ?? = 9.62 (br, 1H), 8.50 (d, J = 7.6 Hz, 4H), vol.7, p.90
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