Intestinally derived bacterial products stimulate development of nonalcoholic steatohepatitis

Waleska Dornas (1) , Vincent Lagente (1)

1 NuMeCan - Nutrition, Métabolismes et Cancer

Fatty livers are susceptible to factors that cause inflammation and fibrosis, but fat deposition and the inflammatory response can be dissociated. While nonalcoholic fatty liver disease (NAFLD), caused by pathologic fat accumulation inside the liver, can remain stable for several years, in other cases NAFLD progresses to nonalcoholic steatohepatitis (NASH), which is characterized by fat accumulation and inflammation and is not a benign condition. In this review, we discuss the NASH host cells and microbial mechanisms that stimulate inflammation and predispose the liver to hepatocyte injury and fibrotic stages via increased lipid deposition. We highlight the interactions between intestine-derived bacterial products, such as lipopolysaccharide, and nutritional models of NAFLD and/or obese individuals. The results of modulating enteric microbiota suggest that gut-derived endotoxins may be essential determinants of fibrotic progression and regression in NASH.

Mots clés: Lipopolysaccharide; Hepatic stellate cell; Gut microbiota; Liver fibrosis; Nonalcoholic steatohepatitis; Inflammation

Domaines: Hépatologie et Gastroentérologie

Waleska Dornas, Vincent Lagente. Intestinally derived bacterial products stimulate development of nonalcoholic steatohepatitis. Pharmacological Research, 2019, 141, pp.418-428. ⟨10.1016/j.phrs.2019.01.026⟩. ⟨hal-02020468⟩