Steatohepatitis: a tale of two "hits, Gastroenterology, vol.114, pp.842-845, 1998. ,
Dietary ?-and ?-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis, J Nutr Biochem, vol.21, pp.1200-1206, 2010. ,
ROR? decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice, Antioxid & Redox Signaling, vol.21, pp.2083-2094, 2014. ,
Nonalcoholic steatohepatitis weakens the acute phase response to endotoxin in rats, Liver Int, vol.34, pp.1584-1592, 2014. ,
Progression of alcoholic and nonalcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress, Drug Metab Pharmacokinet, vol.26, pp.30-46, 2011. ,
Microbiota and nonalcoholic steatohepatitis, Semin Immunopathol, vol.36, pp.115-132, 2014. ,
The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota, Hepatology, vol.63, pp.764-775, 2016. ,
Non-alcoholic steatohepatitis: a microbiota-driven disease, Trend Endocrinol Metab, vol.24, pp.537-545, 2013. ,
DOI : 10.1016/j.tem.2013.05.009
The gut microbiota and the liver. Pathophysiological and clinical implications, J Hepatol, vol.58, pp.1020-1027, 2013. ,
Intestinal mucosal barrier dysfunction participates in the progress of nonalcoholic fatty liver disease, Int J Clin Exp Pathol, vol.8, pp.3648-3658, 2015. ,
Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis, Proc Nat Acad Sci, vol.94, pp.2557-2562, 1997. ,
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease, Hepatology, vol.37, pp.343-350, 2003. ,
DOI : 10.1053/jhep.2003.50048
URL : https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1053/jhep.2003.50048
The Gordian Knot of dysbiosis, obesity and NAFLD, Nat Rev Gastroenterol Hepatol, vol.10, pp.637-644, 2013. ,
Pro-Inflammatory cytokines but not endotoxin-related parameters associate with disease severity in patients with NAFLD, PLoS One, vol.11, p.16604, 2016. ,
Association between endotoxemia and histological features of nonalcoholic fatty liver disease, World J Gastroenterol, vol.23, pp.712-722, 2017. ,
Intestinal microbiota in patients with nonalcoholic fatty liver disease, Hepatology, vol.58, pp.120-127, 2013. ,
Meta-omic platforms to assist in the understanding of NAFLD gut microbiota alterations: tools and applications, Int J Mol Sci, vol.15, pp.684-711, 2014. ,
Gut microbiota and liver disease, J Gastroenterol Hepatol, vol.29, pp.1139-1148, 2014. ,
DOI : 10.1111/jgh.12556
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1111/jgh.12556
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism, Gut, vol.66, pp.620-632, 2017. ,
DOI : 10.1136/gutjnl-2015-310904
URL : https://gut.bmj.com/content/66/4/620.full.pdf
Hyperresponsivity to lowdose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling, Cell Metab, vol.16, pp.44-54, 2012. ,
Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet, World J Gastroenterol, vol.14, pp.6655-6661, 2008. ,
Gut microbiota and nonalcoholic fatty liver disease, Ann Hepatol, vol.11, pp.440-449, 2012. ,
Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR4 and CD14, Am J Pathol, vol.182, pp.375-387, 2013. ,
Toll-like receptor 4 and hepatic fibrogenesis, Semin Liver Dis, vol.30, pp.232-244, 2010. ,
DOI : 10.1055/s-0030-1255353
URL : http://europepmc.org/articles/pmc4099360?pdf=render
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis, Hepatology, vol.52, pp.1836-1846, 2010. ,
Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis, PLoS One, vol.8, p.65211, 2013. ,
Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4, Alcohol Clin Exp Res, vol.29, pp.140-145, 2005. ,
DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model, Biochem Biophys Res Commun, vol.470, pp.15-21, 2016. ,
DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH, J Hepatol, vol.55, pp.1391-1399, 2011. ,
Lipopolysaccharide triggered TNF-alphainduced hepatocyte apoptosis in a murine nonalcoholic steatohepatitis model, J Hepatol, vol.51, pp.168-175, 2009. ,
Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children, J Pediatr Gastroenterol Nutr, vol.50, pp.645-649, 2010. ,
LPS-induced TNF-? factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease, Oncotarget, vol.6, pp.41434-41452, 2015. ,
Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis, Dig Dis Sci, vol.52, pp.2520-2524, 2007. ,
Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency, J Gastroenterol Hepatol, vol.21, pp.174-182, 2006. ,
Nonalcoholic fatty liver disease: Roles of the gut and the liver and metabolic modulation by some dietary factors and especially long-chain n-3 PUFA, Mol Nutr Food Res, vol.60, pp.147-159, 2016. ,
Effect of lipopolysaccharide on the progression of non-alcoholic fatty liver disease in high caloric diet-fed mice, Scand J Immunol, vol.83, pp.109-118, 2015. ,
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistance mice, Proc Nat Acad Sci, vol.103, pp.12511-12516, 2006. ,
Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency, Gastroenterology, vol.140, pp.976-986, 2011. ,
The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice, Hepatology, vol.60, pp.1593-1596, 2014. ,
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia, Hepatology, vol.59, pp.858-869, 2014. ,
Involvement of resistin-like molecule ? in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice, Sci Rep, vol.6, 2016. ,
A novel antihypoglycemic role of inducible nitric oxide synthase in liver inflammatory response induced by dietary cholesterol and endotoxemia, Antioxid Redox Signal, vol.19, pp.1889-1901, 2013. ,
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis, J Hepatol, vol.57, pp.141-149, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01004738
Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, vol.56, pp.1761-1772, 2007. ,
Hepatocyte Toll-Like Receptor 5 promotes bacterial clearance and protects mice against high-fat diet-induced liver disease, Cell Mol Gastroenterol Hepatol, vol.2, pp.584-604, 2016. ,
Distinctly altered gut microbiota in the progression of liver disease, Oncotarget, vol.7, pp.19355-19366, 2016. ,
Obesity alters gut microbial ecology, Proc Nat Acad Sci, vol.102, pp.11070-11075, 2005. ,
DOI : 10.1073/pnas.0504978102
URL : http://www.pnas.org/content/102/31/11070.full.pdf
Microbial ecology: human gut microbes associated with obesity, Nature, vol.444, pp.1022-1023, 2006. ,
An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, vol.444, pp.1027-1031, 2006. ,
Modulation of gut microbiota by Berberine improves steatohepatitis in high-fat diet-fed BALB/C mice, Arch Iran Med, vol.19, pp.197-203, 2016. ,
Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1?-induced chronic inflammation, Lab Invest, vol.94, pp.491-502, 2014. ,
DOI : 10.1038/labinvest.2014.11
URL : https://www.nature.com/articles/labinvest201411.pdf
Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota, Sci Rep, vol.7, p.1529, 2017. ,
The impact of small doses of LPS on NASH in high sucrose and high fat diet induced rats, Eur Rev Med Pharmacol Sci, vol.18, pp.2742-2747, 2014. ,
Development of fibrosis in nonalcoholic steatosis through combination of a synthetic diet rich in disaccharide and lowdose lipopolysaccharides in the livers of Zucker (fa/fa) rats, J Clin Biochem Nutr, vol.45, pp.322-328, 2009. ,
Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates, Am J Clin Nutr, vol.98, pp.349-357, 2013. ,
DOI : 10.3945/ajcn.112.057331
URL : https://academic.oup.com/ajcn/article-pdf/98/2/349/23828792/349.pdf
) ?-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice, PLoS One, vol.9, p.98294, 2014. ,
DOI : 10.1371/journal.pone.0098294
URL : https://doi.org/10.1371/journal.pone.0098294
TLR4 enhances TGF-beta signaling and hepatic fibrosis, Nat Med, vol.13, pp.1324-1332, 2007. ,
DOI : 10.1038/nm1663
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis, Fibrogenesis Tissue Repair, vol.3, p.21, 2010. ,
DOI : 10.1186/1755-1536-3-21
URL : https://fibrogenesis.biomedcentral.com/track/pdf/10.1186/1755-1536-3-21
Pathophysiology of NASH: perspectives for a targeted treatment, Curr Pharm Des, vol.19, pp.5250-5269, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00801356
Humanbased systems: Mechanistic NASH modelling just around the corner?, Pharmacol Res, vol.134, pp.257-267, 2018. ,
DOI : 10.1016/j.phrs.2018.06.029
URL : https://doi.org/10.1016/j.phrs.2018.06.029
Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease, Clin Exp Immunol, vol.166, pp.281-290, 2011. ,
Molecular pathogenesis of NASH, Int J Mol Sci, vol.20, p.17, 2016. ,
DOI : 10.3390/ijms17091575
URL : https://www.mdpi.com/1422-0067/17/9/1575/pdf
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, vol.482, pp.179-185, 2012. ,
DOI : 10.1038/nature10809
URL : http://europepmc.org/articles/pmc3276682?pdf=render
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells, Hepatology, vol.54, pp.133-144, 2011. ,
DOI : 10.1002/hep.24341
URL : https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.24341
Pathogenesis of nonalcoholic steatohepatitis, Cell Mol Life Sci, vol.73, pp.1969-1987, 2016. ,
Shortchain fatty acid topical treatment in distal ulcerative colitis, Aliment Pharmacol Therap, vol.9, pp.309-313, 1995. ,
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43, Nature, vol.461, pp.1282-1286, 2009. ,
Gut microbiome and nonalcoholic fatty liver diseases, Pediatr Res, vol.77, pp.245-251, 2015. ,
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules, Pharmacol Res, vol.104, pp.9-21, 2016. ,
Tissue-specific function of farnesoid X receptor in liver and intestine, Pharmacol Res, vol.63, issue.4, pp.259-265, 2011. ,
, Microbiota, NASH, HCC and the potential role of probiotics, vol.38, pp.231-240, 2017.
Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet, J Pharmacol Exp Ther, vol.328, pp.116-122, 2009. ,
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease, J Biol Chem, vol.288, pp.11761-11770, 2013. ,
Intestinal microbiota in liver disease, Best Pract Res Clin Gastroenterol, vol.4, pp.133-142, 2016. ,
Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence, Transl Res, vol.167, pp.116-124, 2016. ,
Future trends in the treatment of non-alcoholic steatohepatitis, Pharmacol Res, vol.134, pp.289-298, 2018. ,
A pill a day can improve survival in patients with advanced cirrhosis, Gastroenterology, vol.133, pp.1029-1031, 2007. ,
Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice, J Hepatol, vol.56, pp.893-899, 2012. ,
Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis, Gastroenterology, vol.133, pp.818-824, 2007. ,
Changes in gut microbiota control metabolic endotoxemia induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, vol.57, pp.1470-1481, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00410066
Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole, irrespective of protein calorie malnutrition, Gastroenterology, vol.82, pp.535-548, 1982. ,
Antibiotics protect against fructose induced hepatic lipid accumulation in mice: role of endotoxin, J Hepatol, vol.48, pp.983-992, 2008. ,
Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline, Gastroenterology, vol.100, pp.513-519, 1991. ,
Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat dietinduced steatohepatitis, BMC Gastroenterol, vol.29, p.136, 2017. ,
Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease, Eur J Gastroenterol Hepatol, vol.27, pp.840-845, 2015. ,
Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model, Mol Med Rep, vol.11, pp.1693-1700, 2015. ,
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice, FASEB J, vol.22, pp.2416-2426, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00409179
Antibiotic prophylaxis in cirrhosis: Good and bad, Hepatology, vol.63, issue.6, pp.2019-2031, 2016. ,
Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat, Hepatology, vol.25, pp.642-647, 1997. ,
Gut-liver axis: a new point of attack to treat chronic liver damage?, Am J Gastroenterol, vol.97, pp.2144-2146, 2002. ,
Endotoxin-and D-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry, Dig Liv Dis, vol.39, pp.849-856, 2007. ,
Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis, Hepatology, vol.46, pp.841-85, 2007. ,
Probiotics as a novel treatment for non-alcoholic fatty liver disease; a systematic review on the current evidences, Hepat Mon, vol.13, p.7233, 2013. ,
Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia, Sci Rep, vol.7, p.45176, 2017. ,
Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial, Eur Rev Med Pharmacol Sci, vol.9, pp.1090-1095, 2011. ,
Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases, J Clin Gastroenterol, vol.39, pp.540-543, 2005. ,
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice, Hepatology, vol.49, pp.989-997, 2009. ,
The effect of a probiotic on hepatic steatosis, J Clin Gastroenterol, vol.42, issue.10, pp.1117-1119, 2008. ,
Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats, J Nutr, vol.139, pp.905-911, 2009. ,
VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation, PLoS One, vol.7, p.45425, 2012. ,
Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, Gastroenterology, vol.147, pp.1327-1337, 2014. ,
Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model, J Nutr Biochem, vol.24, pp.531-538, 2012. ,
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model, Am J Physiol Gastrointest Liver Physiol, vol.305, pp.911-918, 2013. ,
Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice, PLoS One, vol.27, issue.1, p.80169, 2014. ,
Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis: A pilot trial, J Dig Dis, vol.18, issue.12, pp.698-703, 2017. ,
Prebiotics and probiotics: are they functional foods?, Am J Clin Nutr, vol.71, pp.1682-1687, 2000. ,
The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance, Liver Int, vol.32, pp.701-711, 2012. ,
Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese zucker rats, J Nutr, vol.130, pp.1314-1319, 2000. ,
Prebiotic approach alleviates hepatic steatosis: Implication of fatty acid oxidative and cholesterol synthesis pathways, Mol Nutr Food Res, vol.7, pp.347-359, 2013. ,
Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis, Dig Dis Sci, vol.57, pp.545-553, 2012. ,
Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study, Eur J Clin Nutr, vol.59, pp.723-726, 2005. ,
Beneficial effect of synbiotic supplementation on hepatic steatosis and anthropometric parameters, but not on gut permeability in a population with nonalcoholic steatohepatitis, Nutrients, vol.28, issue.7, p.8, 2016. ,
Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats, J Nutr, vol.133, pp.1903-1908, 2003. ,
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability, Gut, vol.58, pp.1091-1103, 2009. ,
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions, Am J Gastroenterol, vol.94, issue.9, pp.2467-2474, 1999. ,
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells, Hepatology, vol.37, pp.1043-1055, 2003. ,
NF-?B inhibition alleviates carbon tetrachlorideinduced liver fibrosis via suppression of activated hepatic stellate cells, Exp Ther Med, vol.8, issue.1, pp.95-99, 2014. ,
Caffeic acid phenethyl ester attenuates proinflammatory and fibrogenic phenotypes of LPS-stimulated hepatic stellate cells through the inhibition of NF-?B signaling, Int J Mol Med, vol.33, issue.3, pp.687-694, 2014. ,
Differential expression of monocyte chemotactic protein-1 (MCP-1) in transforming rat hepatic stellate cells, J Hepatol, vol.30, issue.1, pp.88-94, 1999. ,
Toll-like receptor 4-independent carbon tetrachlorideinduced fibrosis and lipopolysaccharide-induced acute liver injury in mice: Role of hepatic stellate cells, Am J Pathol, vol.187, pp.1356-1367, 2017. ,
Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell, J Cell Physiol, vol.234, issue.1, pp.122-133, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01880153