Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy, BMC Biol, vol.12, p.94, 2014. ,
Endoplasmic reticulum stress in malignancy, Cancer Cell, vol.25, pp.563-73, 2014. ,
The unfolded protein response and cell fate control, Mol Cell, vol.69, pp.169-81, 2018. ,
Proteasome inhibitors in multiple myeloma: 10 years later, Blood, vol.120, pp.947-59, 2012. ,
Functional profiling of the Saccharomyces cerevisiae genome, Nature, vol.418, pp.387-91, 2002. ,
Targeted deletion ofp97 (VCP/CDC48) in mouse results in early embryonic lethality, Biochem Biophys Res Commun, vol.354, pp.459-65, 2007. ,
An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF, EMBO J, vol.9, pp.1757-67, 1990. ,
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system, Nat Cell Biol, vol.14, pp.117-140, 2012. ,
CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans, J Struct Biol, vol.179, pp.104-115, 2012. ,
p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis, Dev Cell, vol.11, pp.803-819, 2006. ,
Cdc48/p97 mediates UV-dependent turnover of RNA Pol II, Mol Cell, vol.41, pp.82-92, 2011. ,
An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments, Cell, vol.82, pp.905-919, 1995. ,
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy, Nat Cell Biol, vol.9, pp.379-90, 2007. ,
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis, Cell, vol.115, pp.355-67, 2003. ,
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome, eLife, vol.2, p.308, 2013. ,
Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products, Proc Natl Acad Sci, vol.110, pp.5046-51, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01404018
TheAAA ATPase Cdc48/p97and its partners transport proteins from the ER into the cytosol, Nature, vol.414, pp.652-658, 2001. ,
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains, J Cell Biol, vol.162, pp.71-84, 2003. ,
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane, Proc Natl Acad Sci, vol.102, pp.14132-14140, 2005. ,
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD, Autophagy, vol.6, pp.217-244, 2010. ,
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/ VCP-associated disease, J Biol Chem, vol.283, pp.30289-99, 2008. ,
Reversible inhibitor ofp97, DBeQ, impairs both ubiquitindependent and autophagic protein clearance pathways, Proc Natl Acad Sci, vol.108, pp.4834-4843, 2011. ,
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins, Cell, vol.126, pp.361-73, 2006. ,
Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop, Mol Cell, vol.40, pp.147-58, 2010. ,
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition, eLife, vol.3, p.1856, 2014. ,
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97, Curr Biol, vol.24, pp.1573-83, 2014. ,
P97/CDC-48: proteostasis control in tumor cell biology, Cancer Lett, vol.337, pp.26-34, 2013. ,
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death, Nat Chem Biol, vol.9, pp.548-56, 2013. ,
Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis, Cancer Cell, vol.28, pp.653-65, 2015. ,
Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/ p97, Cell Death Dis, vol.6, p.2031, 2015. ,
Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer, Clin Cancer Res, vol.10, pp.3007-3019, 2004. ,
Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma, J Clin Oncol, vol.21, pp.2537-2581, 2003. ,
Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence, J Clin Oncol, vol.21, pp.447-52, 2003. ,
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4, Nature, vol.552, p.194, 2017. ,
The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma, Mol Cancer Ther, vol.16, pp.2375-86, 2017. ,
Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083), J Med Chem, vol.58, pp.9480-97, 2015. ,
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates, Proc Natl Acad Sci, vol.114, pp.3565-71, 2017. ,
Understanding the intersections between metabolism and cancer biology, Cell, vol.168, pp.657-69, 2017. ,
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy, Nat Rev Cancer, vol.16, pp.680-93, 2016. ,
The emerging hallmarks of cancer metabolism, Cell Metab, vol.23, pp.27-47, 2016. ,
Lasparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia, JAMA, vol.202, pp.882-890, 1967. ,
The metabolism of tumors in the body, J Gen Physiol, vol.8, pp.519-549, 1927. ,
Dual requirement of Walker carcinosarcoma 256 in vitro for asparagine and glutamine, Science, vol.124, pp.124-129, 1956. ,
Glutamine metabolism of normal and malignant cells cultivated in synthetic media, Nature, vol.183, pp.1201-1203, 1959. ,
Glutamine supports pancreatic cancer growth through a KRASregulated metabolic pathway, Nature, vol.496, pp.101-106, 2013. ,
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein, Cancer Res, vol.75, pp.544-53, 2015. ,
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation, Nat Cell Biol, vol.18, pp.1090-101, 2016. ,
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer, Cell Metab, vol.23, pp.517-545, 2016. ,
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry, Cancer Res, vol.69, pp.4918-4943, 2009. ,
p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose, Mol Cell, vol.49, pp.1049-59, 2013. ,
AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow, Cell Stem Cell, vol.17, pp.585-96, 2015. ,
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides, Nature, vol.508, pp.108-120, 2014. ,
Keeping the eIF2 alpha kinase Gcn2 in check, Biochim Biophys Acta, vol.1843, pp.1948-68, 2014. ,
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2, Mol Cell Biol, vol.18, pp.2282-97, 1998. ,
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids, Mol Cell Biol, vol.15, pp.4497-506, 1995. ,
Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation, eLife, vol.5, p.14295, 2016. ,
Regulation of starvation-and virus-induced autophagy by the eIF2alpha kinase signaling pathway, Proc Natl Acad Sci, vol.99, pp.190-195, 2002. ,
Phosphorylation of eIF2alpha triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma, Sci Signal, vol.8, p.27, 2015. ,
The eIF2alpha/ATF4 pathway is essential for stress-induced autophagy gene expression, Nucleic Acids Res, vol.41, pp.7683-99, 2013. ,
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2, Genes Dev, vol.29, pp.2331-2337, 2015. ,
Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway, Neoplasia, vol.15, pp.989-97, 2013. ,
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation, EMBO J, vol.29, pp.2082-96, 2010. ,
ERK2 mediates metabolic stress response to regulate cell fate, Mol Cell, vol.59, pp.382-98, 2015. ,
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature, vol.483, pp.603-610, 2012. ,
Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome, Clin Cancer Res, vol.16, pp.1856-64, 2010. ,
Signals from the stressed endoplasmic reticulum induce C/ EBP-homologous protein (CHOP/GADD153), Mol Cell Biol, vol.16, pp.4273-80, 1996. ,
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins, Nature, vol.332, pp.462-466, 1988. ,
Regulated translation initiation controls stress-induced gene expression in mammalian cells, Mol Cell, vol.6, pp.1099-108, 2000. ,
New roles of the fission yeast eIF2alpha kinases Hri1 and Gcn2 in response to nutritional stress, J Cell Sci, vol.126, pp.3010-3030, 2013. ,
Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency, Mol Biol Cell, vol.21, pp.3220-3251, 2010. ,
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation, Nature, vol.531, pp.523-530, 2016. ,
TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy, Proc Natl Acad Sci USA, vol.111, pp.10586-91, 2014. ,
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis, J Cell Sci, vol.127, pp.3877-83, 2014. ,
Protein synthesis upon acute nutrient restriction relies on proteasome function, Science, vol.310, pp.1960-1963, 2005. ,
Failure of amino acid homeostasis causes cell death following proteasome inhibition, Mol Cell, vol.48, pp.242-53, 2012. ,
Glutamine addiction: a new therapeutic target in cancer, Trends Biochem Sci, vol.35, pp.427-460, 2010. ,
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2, J Biol Chem, vol.279, pp.36553-61, 2004. ,
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent Lasparaginase, J Biol Chem, vol.284, pp.32742-32751, 2009. ,
GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment, Am J Physiol Endocrinol Metab, vol.308, pp.283-293, 2015. ,
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice, Mol Cell Biol, vol.22, pp.6681-6689, 2002. ,
SUnSET, a nonradioactive method to monitor protein synthesis, Nat Methods, vol.6, pp.275-282, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00408410
clusterProfiler: an R package for comparing biological themes among gene clusters, OMICS, vol.16, pp.284-291, 2012. ,
The igraph software package for complex network research, InterJournal Complex Syst, vol.1695, pp.1-9, 2006. ,
FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry, Anal Chem, vol.81, pp.10038-10086, 2009. ,
A software complement to AMDIS for processing GC-MS metabolomic data, Anal Biochem, vol.415, pp.206-214, 2011. ,
Controlling the false discovery rate -a practical and powerful approach to multiple testing, J Royal Stat Soc B Stat Methadol, vol.57, pp.289-300, 1995. ,