. Mhz, CDCl 3 ): ? 151.5 (C), 150.7 (C), 148.4 (C), 142.0 (C), 139.5 (C), 139.1 (C), 135.4 (CH), 135.1 (2CH), vol.133, pp.884-885, 1139.

, Compound (±)-2k: According to the representative procedure, starting from compound (±)-3a (100 mg, 0.45 mmol); flash chromatography on silica gel (DCM/Cy, 1:1) gave compound (±)-2k (98 mg, 52% yield) as amorphous white solid. 1 H NMR (500 MHz, HRMS (ESI): m/z

, Representative procedure for the gold-catalysed intramolecular cyclization: synthesis of compound (±)-1a. A 2-6 mL microwave vial was charged with AuCl 3 (4 mg, 0.013 mmol, 0.08 eq.) and AgSbF 6 (9 mg, 0.026 mmol, 0.16 eq.) under an Argon atmosphere. Dry DCE (1.5 mL) was then added and the resulting mixture was stirred at rt for 5 min. Compound (±)-2a (55 mg, 0.16 mmol, 1 eq.) was finally added. The tube was sealed, then evacuated and refilled with argon three times. The solution was irradiated in a microwave reactor at 80 °C for 7 min, 127.5 (CH), 125.5 (q, J = 3.6 Hz, 2CH), 123.5 (q, J = 270.9 Hz, CF 3 ), 123.2 (C), vol.132, p.716, 1066.

. Mhz, HRMS (ESI): m/z [M+H] + calcd for C 25 H 21 O 2 : 353.1535; found: 353.1545. Compound (±)-1b: According to the representative procedure, starting from compound (±)-2b (40 mg, 0.14 mmol); flash chromatography on silica gel (EtOAc/Cy, 3:17) gave compound (±)-1b (26 mg, 65% yield) as amorphous white solid. 1 H NMR (500 MHz, CDCl 3 ): ? 6.74 (d, J = 7.7 Hz, 1H), 6.63 (d, J = 7.7 Hz, 1H), 6.56 (ddd, J = 9, vol.132, p.2924, 0914.

, starting from compound (R p )-2b (45 mg, 0.16 mmol); flash chromatography on silica gel (EtOAc/Cy, 2:8) gave compound (S p )-1b (23 mg, 51% yield, 95% ee) as amorphous white solid, vol.20, p.520

, Compound (±)-1c: According to the representative procedure, starting from compound (±)-2c (40 mg, 0.13 mmol); flash chromatography on silica gel (EtOAc/Cy, 1:9) gave compound (±)-1c (22 mg, 55% yield) as amorphous white solid. 1 H NMR (500 MHz, CDCl 3 ): ? 6.72 (d, J = 7.7 Hz, 1H), 6.62 (d, J = 7.7 Hz, 1H), 6.56 (ddd, J = 7.2, 5.0, 1.8 Hz, 2H), vol.6, pp.682-683, 0918.

, Compound (±)-1d: According to the representative procedure, starting from compound (±)-2c (32 mg, 0.12 mmol); flash chromatography on silica gel (EtOAc/Cy, 1:9) gave compound (±)-1d (13 mg, 41% yield) as amorphous white solid. 1 H NMR (500 MHz, HRMS

. Hz,

, 63 mmol); flash chromatography on silica gel (EtOAc/Cy, 1:14 to 1:9) gave compound (±)-1e (234 mg, 86% yield) as amorphous white solid. 1 H NMR (500 MHz, 139.8 (2C), 137.5 (C), vol.136, p.731, 1120.

. Hz, 1H), 6.56 (d, J = 1.5 Hz, 1H), 6.34 (s, 1H), 6.30 (d

. Hz,

. Hz, HRMS (ESI): m/z [M+H] + calcd for C 25 H 20 O 2 Br: 431.0641; found: 431.0648. Compound (±)-1f: According to the representative procedure, starting from compound (±)-2f (100 mg, 0.27 mmol); flash chromatography on silica gel (EtOAc/Cy, 3:17) gave compound (±)-1f (72 mg, 72% yield) as amorphous white solid. 1 H NMR (500 MHz, 127.6 (C), 126.8 (br, CH) 126.6 (CH), 126.3 (C), 120.8 (C), 116.0 (CH), vol.129, pp.730-731, 1031.

. Hz,

. Hz, Compound (±)-1h: According to the representative procedure, starting from compound (±)-2h (40 mg, 0.11 mmol); flash chromatography on silica gel (EtOAc/Cy, 1:9) gave compound (±)-1h (32 mg, m, 1H) ppm. 13 C NMR (125 MHz, CDCl 3 ): ? 161.0 (C), 156.2 (C), 154.2 (C), 141.3 (C), 139.8 (C), 139.4 (C), 138.0 (C), 136.5 (CH), 135.4 (C, vol.132, p.125, 0911.

. Mhz, 1 (CH), 131.6 (CH), 130.5 (C), CDCl 3 ): ? 161.1 (C), 160.8 (C), 155.8 (C), 154.2 (C), 141.3 (C), 139.4 (C), 138.0 (C), 136.5 (CH), vol.132, pp.731-732, 0913.

, Compound (±)-1j: According to the representative procedure, starting from compound (±)-2j (15 mg, 0.03 mmol); flash chromatography on silica gel (EtOAc/Cy, 2:8) gave compound (±)-1j (10 mg, 67% yield) as amorphous white solid. 1 H NMR (500 MHz, Compound (±)-1i: According to the representative procedure, starting from compound (±)-2i (48 mg, 0.12 mmol); flash chromatography on silica gel (EtOAc/Cy, 3:17) gave compound (±)-1i (29 mg, 60% yield) as amorphous white solid. 1 H NMR (500 MHz, CDCl 3 ): ? 7.72-7.09 (br m, 4H), 6.81 (d, J = 7.7 Hz, 1H), 6.63 (t, J = 8.1 Hz, 2H), 6.48 (s, 2H), 6.35-6.24 (m, 2H), 3.68 (ddd, J = 13.5, 10.5, 2.8 Hz, 1H), 3.22 (ddd, J = 13.2, 10.5, 5.0 Hz, 1H), 3.10 (ddd, J = 13.2, 10.9, 2.8 Hz, 1H), 2.89-2.80 (m, 1H), 2.76 (ddd, J = 13.5, 10.9, 5.0 Hz, 1H), vol.140, pp.137-144, 0913.

, HRMS (ESI): m/z [M+H] + calcd for C 26 H 20 O 5 F 3 S: 501.0978; found: 501.0988. Compound (±)-1k: According to the representative procedure, starting from compound (±)-2k (45 mg, 0.11 mmol); flash chromatography on silica gel (EtOAc/Cy, 1:9) gave compound (±)-1b (23 mg, 51% yield) as amorphous white solid. 1 H NMR (500 MHz, vol.846, pp.731-732, 1036.

, q, J = 33 Hz, C), 128.6 (C, vol.131

, 38 mg, 0.325 mmol, 3.5 eq.). The vial was sealed with a septum, then evacuated and refilled with argon three times through a needle. Dry toluene (0.2 mL) was added via syringe and the resulting solution was heated at 85 °C in an oil bath overnight. The mixture was then cooled to rt, diluted with H 2 O (15 mL), and extracted with AcOEt (3 x 10 mL). The combined organic layers (EtOAc) were filtered over Celite ® and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using EtOAc/Cy (9:1 to 8:2) as the eluent to afford compound (±)-1l (18 mg, 0.041 mmol, 44% yield) as an amorphous white solid. 1 H NMR (500 MHz, CDCl 3 ): ? 7.74-7.33 (br m, 5H), 6.93 (s, 1H), 6.83 (d, J = 7.7 Hz, 1H), 6.75 (d, J = 7.7 Hz, 1H), 6.43 (dd, J = 7.8, 1.5 Hz, 1H), 6.33 (s, 1H), 6.25 (d, J = 7.8 Hz, 1H), 6.09 (s, 1H), 3.72-3.67 (m, 1H), 3.17-3.13 (m, 1H), 3.09-2.99 (m, 1H), 2.87-2.71 (m, 2H), vol.845, p.750, 0977.

, The combined organic layers (DCM) were washed with H 2 O (2 x 10 mL), and brine (2 x 10 mL), then concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: EtOAc/pentane 3:7) to afford compound (±)-1m (15 mg, 0.041 mmol, 92% yield) as an amorphous yellow solid. 1 H NMR (500 MHz, eq.) was added and the reaction was stirred at rt overnight. The mixture was quenched with a saturated aq. NaHCO 3 solution (15 mL), and extracted with DCM (3 x 10 mL), vol.7

, HRMS (ESI): m/z [M+H] + calcd for C 30 H 30 O 4 N: 468.2169; found: 468.2179. Synthesis of compound (±)-1o: Compound (±)-1m (19 mg, 0.041 mmol, 1 eq.) was placed in a 10 mL round-bottomed flask and dissolved in DCM (0.5 mL). TFA (0.03 mL, 0.40 mmol, 10 eq.) was added and the reaction was stirred at rt overnight. The mixture was quenched with a saturated aq. NaHCO 3 solution (15 mL), and extracted with DCM (3 x 10 mL). The combined organic layers (DCM) were washed with H 2 O (2 x 10 mL), and brine (2 x 10 mL), then concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using EtOAc/pentane (2:8 to 4:6) as the eluent to afford compound (±)-1o (12 mg, 0.032 mmol, 78% yield) as an amorphous yellow solid. 1 H NMR (500 MHz, CDCl 3 ) ? 7.70-7.06 (br m, 4H), 6.79 (d, J = 7.6 Hz, 1H), 6.74-6.55 (m, 3H), vol.126, pp.736-737, 0918.

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