Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis a prospective observational study

Nicolas Nesseler (1) , Corinne Martin-Chouly (2) , Harmonie Perrichet (3) , James T Ross (4) , Chloé Rousseau (5) , Pratik Sinha (4) , Sonia Isslame (3) , Elodie Masseret (3) , Yannick Mallédant (1) , Yoann Launey (1) , Philippe Seguin (1)

1 NuMeCan - Nutrition, Métabolismes et Cancer
2 Irset - Institut de recherche en santé, environnement et travail
3 CHU Pontchaillou [Rennes]
4 UC San Francisco - University of California [San Francisco]
5 CIC - Centre d'Investigation Clinique [Rennes]

Keywords: prognosis; SOFA score; cytokines; endotoxin; lipopolysaccharide; immunosuppression

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Immunology

Nicolas Nesseler, Corinne Martin-Chouly, Harmonie Perrichet, James T Ross, Chloé Rousseau, et al.. Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis a prospective observational study. Anaesthesia Critical Care & Pain Medicine, 2019, 38 (5), pp.485-491. ⟨10.1016/j.accpm.2019.01.009⟩. ⟨hal-02049818⟩